Dietary intake of metals and risk of Parkinson's disease: A case-control study in Japan

Yoshihiro Miyake, Keiko Tanaka, Wakaba Fukushima, Satoshi Sasaki, Chikako Kiyohara, Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oeda, Takami Miki, Nobutoshi Kawamura, Nobutaka Sakae, Hidenao Fukuyama, Yoshio Hirota, Masaki Nagai, Yasuhiko Baba, Tomonori Kobayashi, Hideyuki Sawada, Eiji Mizuta, Nagako Murase, Tsuyoshi TsutadaHiroyuki Shimada, Jun Ichi Kira, Tameko Kihira, Tomoyoshi Kondo, Hidekazu Tomimoto, Takayuki Taniwaki, Hiroshi Sugiyama, Sonoyo Yoshida, Harutoshi Fujimura, Tomoko Saito, Kyoko Saida, Junko Fujitake, Naoki Fujii, Masatoshi Naito, Jun Arimizu, Takashi Nakagawa, Hirofumi Harada, Takayuki Sueta, Toshihiro Kikuta, George Umemoto, Eiichi Uchio, Hironori Migita, Kenichi Kazuki, Yoichi Ito, Hiroyoshi Iwaki, Kunihiko Siraki, Shinsuke Ataka, Hideo Yamane, Rie Tochino, Teruichi Harada, Yasushi Iwashita, Motoyuki Shimizu, Kenji Seki, Keiji Ando

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Metals are involved in several important functions in the nervous system. Zinc and iron are increased and copper is decreased in the substantia nigra in Parkinson's disease (PD). However, epidemiological evidence for the association of dietary intake of metals with the risk of PD is limited. We investigated the relationship between metal consumption and the risk of PD in Japan using data from a multicenter hospital-based case-control study. Included were 249 cases within 6 years of onset of PD based on the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a self-administered diet history questionnaire. Higher intake of iron, magnesium, and zinc was independently associated with a reduced risk of PD: the adjusted OR in the highest quartile was 0.24 (95% CI: 0.10-0.57, P for trend = 0.0003) for iron, 0.33 (95% CI: 0.13-0.81, P for trend = 0.007) for magnesium and 0.50 (95% CI: 0.26-0.95, P for trend = 0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalJournal of the Neurological Sciences
Volume306
Issue number1-2
DOIs
Publication statusPublished - Jul 15 2011

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Parkinson Disease
Case-Control Studies
Japan
Metals
Zinc
Iron
Magnesium
Copper
Substantia Nigra
Manganese
Neurodegenerative Diseases
Nervous System
Inpatients
Outpatients
Diet
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Dietary intake of metals and risk of Parkinson's disease : A case-control study in Japan. / Miyake, Yoshihiro; Tanaka, Keiko; Fukushima, Wakaba; Sasaki, Satoshi; Kiyohara, Chikako; Tsuboi, Yoshio; Yamada, Tatsuo; Oeda, Tomoko; Miki, Takami; Kawamura, Nobutoshi; Sakae, Nobutaka; Fukuyama, Hidenao; Hirota, Yoshio; Nagai, Masaki; Baba, Yasuhiko; Kobayashi, Tomonori; Sawada, Hideyuki; Mizuta, Eiji; Murase, Nagako; Tsutada, Tsuyoshi; Shimada, Hiroyuki; Kira, Jun Ichi; Kihira, Tameko; Kondo, Tomoyoshi; Tomimoto, Hidekazu; Taniwaki, Takayuki; Sugiyama, Hiroshi; Yoshida, Sonoyo; Fujimura, Harutoshi; Saito, Tomoko; Saida, Kyoko; Fujitake, Junko; Fujii, Naoki; Naito, Masatoshi; Arimizu, Jun; Nakagawa, Takashi; Harada, Hirofumi; Sueta, Takayuki; Kikuta, Toshihiro; Umemoto, George; Uchio, Eiichi; Migita, Hironori; Kazuki, Kenichi; Ito, Yoichi; Iwaki, Hiroyoshi; Siraki, Kunihiko; Ataka, Shinsuke; Yamane, Hideo; Tochino, Rie; Harada, Teruichi; Iwashita, Yasushi; Shimizu, Motoyuki; Seki, Kenji; Ando, Keiji.

In: Journal of the Neurological Sciences, Vol. 306, No. 1-2, 15.07.2011, p. 98-102.

Research output: Contribution to journalArticle

Miyake, Y, Tanaka, K, Fukushima, W, Sasaki, S, Kiyohara, C, Tsuboi, Y, Yamada, T, Oeda, T, Miki, T, Kawamura, N, Sakae, N, Fukuyama, H, Hirota, Y, Nagai, M, Baba, Y, Kobayashi, T, Sawada, H, Mizuta, E, Murase, N, Tsutada, T, Shimada, H, Kira, JI, Kihira, T, Kondo, T, Tomimoto, H, Taniwaki, T, Sugiyama, H, Yoshida, S, Fujimura, H, Saito, T, Saida, K, Fujitake, J, Fujii, N, Naito, M, Arimizu, J, Nakagawa, T, Harada, H, Sueta, T, Kikuta, T, Umemoto, G, Uchio, E, Migita, H, Kazuki, K, Ito, Y, Iwaki, H, Siraki, K, Ataka, S, Yamane, H, Tochino, R, Harada, T, Iwashita, Y, Shimizu, M, Seki, K & Ando, K 2011, 'Dietary intake of metals and risk of Parkinson's disease: A case-control study in Japan', Journal of the Neurological Sciences, vol. 306, no. 1-2, pp. 98-102. https://doi.org/10.1016/j.jns.2011.03.035
Miyake, Yoshihiro ; Tanaka, Keiko ; Fukushima, Wakaba ; Sasaki, Satoshi ; Kiyohara, Chikako ; Tsuboi, Yoshio ; Yamada, Tatsuo ; Oeda, Tomoko ; Miki, Takami ; Kawamura, Nobutoshi ; Sakae, Nobutaka ; Fukuyama, Hidenao ; Hirota, Yoshio ; Nagai, Masaki ; Baba, Yasuhiko ; Kobayashi, Tomonori ; Sawada, Hideyuki ; Mizuta, Eiji ; Murase, Nagako ; Tsutada, Tsuyoshi ; Shimada, Hiroyuki ; Kira, Jun Ichi ; Kihira, Tameko ; Kondo, Tomoyoshi ; Tomimoto, Hidekazu ; Taniwaki, Takayuki ; Sugiyama, Hiroshi ; Yoshida, Sonoyo ; Fujimura, Harutoshi ; Saito, Tomoko ; Saida, Kyoko ; Fujitake, Junko ; Fujii, Naoki ; Naito, Masatoshi ; Arimizu, Jun ; Nakagawa, Takashi ; Harada, Hirofumi ; Sueta, Takayuki ; Kikuta, Toshihiro ; Umemoto, George ; Uchio, Eiichi ; Migita, Hironori ; Kazuki, Kenichi ; Ito, Yoichi ; Iwaki, Hiroyoshi ; Siraki, Kunihiko ; Ataka, Shinsuke ; Yamane, Hideo ; Tochino, Rie ; Harada, Teruichi ; Iwashita, Yasushi ; Shimizu, Motoyuki ; Seki, Kenji ; Ando, Keiji. / Dietary intake of metals and risk of Parkinson's disease : A case-control study in Japan. In: Journal of the Neurological Sciences. 2011 ; Vol. 306, No. 1-2. pp. 98-102.
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