Dietary intakes of α-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men

Kalpana Poudel-Tandukar, Akiko Nanri, Yumi Matsushita, Satoshi Sasaki, Masanori Ohta, Masao Sato, Tetsuya Mizoue

Research output: Contribution to journalArticle

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Abstract

Investigations suggest a protective role of n-3 polyunsaturated fatty acids (PUFA) but opposing roles of n-6 PUFA in inflammation, but the effects in vivo the human are not clear. We therefore tested the hypothesis that higher intakes of n-3 PUFA and n-6 PUFA are associated with lower levels of inflammation among a population consuming a diet high in PUFA. This study aimed to assess the association between PUFA intake and serum C-reactive protein (CRP) concentrations in a group of Japanese employees. The study subjects were 300 men and 211 women aged 21 to 67 years working in 2 municipal offices of Japan. We measured the serum high-sensitivity CRP concentrations by the latex agglutination nephelometry method and assessed dietary habits by a validated self-administered diet history questionnaire. We analyzed the data using multiple linear regression analysis with adjustment for potential confounding variables. Mean serum CRP concentrations tended to decrease as the intake of eicosapentaenoic acid, docosahexaenoic acid, or their combination increased in men and women, although none of these relationships was statistically significant. In men, there were statistically significant inverse relationships between dietary intake of n-3 or n-6 PUFA and serum CRP concentrations (P for trend = .03 and .008, respectively). Among specific PUFA, only α-linolenic acid and linoleic acid showed clear inverse relationships (P for trend = .001 and .003, respectively) in men. The results suggest that increased intake of not only α-linolenic acid (n-3 PUFA) but also linoleic acid (n-6 PUFA) has a beneficial effect on systemic inflammation in men.

Original languageEnglish
Pages (from-to)363-370
Number of pages8
JournalNutrition Research
Volume29
Issue number6
DOIs
Publication statusPublished - Jun 1 2009

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Linolenic Acids
Linoleic Acids
Unsaturated Fatty Acids
C-Reactive Protein
Blood Proteins
Omega-3 Fatty Acids
Inflammation
Nephelometry and Turbidimetry
Diet
alpha-Linolenic Acid
Eicosapentaenoic Acid
Confounding Factors (Epidemiology)
Docosahexaenoic Acids
Agglutination
Latex
Feeding Behavior
Linoleic Acid
Linear Models
Japan
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Dietary intakes of α-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. / Poudel-Tandukar, Kalpana; Nanri, Akiko; Matsushita, Yumi; Sasaki, Satoshi; Ohta, Masanori; Sato, Masao; Mizoue, Tetsuya.

In: Nutrition Research, Vol. 29, No. 6, 01.06.2009, p. 363-370.

Research output: Contribution to journalArticle

Poudel-Tandukar, Kalpana ; Nanri, Akiko ; Matsushita, Yumi ; Sasaki, Satoshi ; Ohta, Masanori ; Sato, Masao ; Mizoue, Tetsuya. / Dietary intakes of α-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. In: Nutrition Research. 2009 ; Vol. 29, No. 6. pp. 363-370.
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