Dietary intakes of retinol, carotenes, Vitamin C, and Vitamin e and colorectal cancer risk

The Fukuoka colorectal cancer study

Zhenjie Wang, Amit Man Joshi, Ohnaka Keizo, Makiko Morita, Kengo Toyomura, Suminori Kono, Takashi Ueki, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunami, Kenji Takenaka, Hitoshi Ichimiya, Reiji Terasaka

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

It has long been a matter of interest whether antioxidant vitamins are protective against colorectal cancer as well as human cancers in general, but epidemiological evidence is inconclusive. We investigated associations of dietary intakes of retinol and antioxidant vitamins with colorectal cancer risk in 816 incident cases of histologically confirmed colorectal cancer and 815 controls randomly selected for the Fukuoka colorectal cancer study in Japan. Dietary intakes were assessed by a PC-assisted interview regarding 148 food items. Statistical adjustment was made for body mass index, physical activity, calcium, and n-3 fatty acid intake and other factors. Retinol intake was significantly, inversely associated with colorectal cancer risk; the odds ratio for the highest vs. lowest was 0.55 (95% CI: 0.35, 0.88; Ptrend = 0.01) in women, but a modest increase in the risk was observed among men with the highest intake of retinol. Liver was the major source of retinol intake and showed similar associations with colorectal cancer risk in men and women. Intake of carotenes, vitamin C, and vitamin E were not related to colorectal cancer risk in either men or women. The study did not support a hypothesis that dietary intake of antioxidant vitamins is protective in the development of colorectal cancer.

Original languageEnglish
Pages (from-to)798-805
Number of pages8
JournalNutrition and Cancer
Volume64
Issue number6
DOIs
Publication statusPublished - Aug 1 2012

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Carotenoids
Vitamin A
Vitamins
Ascorbic Acid
Colorectal Neoplasms
Antioxidants
Omega-3 Fatty Acids
Vitamin E
Japan
Body Mass Index
Odds Ratio
Interviews
Exercise
Calcium
Food
Liver

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Dietary intakes of retinol, carotenes, Vitamin C, and Vitamin e and colorectal cancer risk : The Fukuoka colorectal cancer study. / Wang, Zhenjie; Joshi, Amit Man; Keizo, Ohnaka; Morita, Makiko; Toyomura, Kengo; Kono, Suminori; Ueki, Takashi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Takeshi; Ikejiri, Koji; Futami, Kitaroh; Maekawa, Takafumi; Yasunami, Yohichi; Takenaka, Kenji; Ichimiya, Hitoshi; Terasaka, Reiji.

In: Nutrition and Cancer, Vol. 64, No. 6, 01.08.2012, p. 798-805.

Research output: Contribution to journalArticle

Wang, Z, Joshi, AM, Keizo, O, Morita, M, Toyomura, K, Kono, S, Ueki, T, Tanaka, M, Kakeji, Y, Maehara, Y, Okamura, T, Ikejiri, K, Futami, K, Maekawa, T, Yasunami, Y, Takenaka, K, Ichimiya, H & Terasaka, R 2012, 'Dietary intakes of retinol, carotenes, Vitamin C, and Vitamin e and colorectal cancer risk: The Fukuoka colorectal cancer study', Nutrition and Cancer, vol. 64, no. 6, pp. 798-805. https://doi.org/10.1080/01635581.2012.690927
Wang, Zhenjie ; Joshi, Amit Man ; Keizo, Ohnaka ; Morita, Makiko ; Toyomura, Kengo ; Kono, Suminori ; Ueki, Takashi ; Tanaka, Masao ; Kakeji, Yoshihiro ; Maehara, Yoshihiko ; Okamura, Takeshi ; Ikejiri, Koji ; Futami, Kitaroh ; Maekawa, Takafumi ; Yasunami, Yohichi ; Takenaka, Kenji ; Ichimiya, Hitoshi ; Terasaka, Reiji. / Dietary intakes of retinol, carotenes, Vitamin C, and Vitamin e and colorectal cancer risk : The Fukuoka colorectal cancer study. In: Nutrition and Cancer. 2012 ; Vol. 64, No. 6. pp. 798-805.
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