TY - JOUR
T1 - Dietary intakes of retinol, carotenes, Vitamin C, and Vitamin e and colorectal cancer risk
T2 - The Fukuoka colorectal cancer study
AU - Wang, Zhenjie
AU - Joshi, Amit Man
AU - Ohnaka, Keizo
AU - Morita, Makiko
AU - Toyomura, Kengo
AU - Kono, Suminori
AU - Ueki, Takashi
AU - Tanaka, Masao
AU - Kakeji, Yoshihiro
AU - Maehara, Yoshihiko
AU - Okamura, Takeshi
AU - Ikejiri, Koji
AU - Futami, Kitaroh
AU - Maekawa, Takafumi
AU - Yasunami, Yohichi
AU - Takenaka, Kenji
AU - Ichimiya, Hitoshi
AU - Terasaka, Reiji
N1 - Funding Information:
This work was financially supported the Scientific Support Programs for Cancer Research, Grant-in-Aid for Scientific Research on Innovative Areas, the Ministry of Education, Culture, Sports, Science and Technology, Japan. The authors acknowledge support from Emeritus Professors Keizo Sug-imachi, Seiyo Ikeda, Sumitaka Arima, and Takayuki Shi-rakusa and from Drs. Motonori Saku, Yoichi Ikeda, Soichiro Maekawa, Kazuo Tanoue, Kinjiro Sumiyoshi, and Shoichiro Saito in conducting the survey of cases. The following physicians kindly supervised the survey of controls at their clinics: Drs. Hideaki Baba, Tomonori Endo, Hiroshi Hara, Yoichiro Hi-rokata, Motohisa Ikeda, Masayoshi Ishibashi, Fumiaki Itoh, Ya-suhiro Iwanaga, Hideki Kaku, Shoshi Kaku, Minoru Kanazawa, Akira Kobayashi, Ryunosuke Kumashiro, Shinichi Matsumoto, Soukei Mioka, Umeji Miyakoda, Osamu Nakagaki, Nobuyoshi Nogawa (deceased), Nobuyuki Ogami, Toyoaki Okabayashi, Hironao Okabe, Nishiki Saku, Masafumi Tanaka, Masahiro Ueda, Bunichi Ushio, and Koheisho Yasunaga.
PY - 2012/8/1
Y1 - 2012/8/1
N2 - It has long been a matter of interest whether antioxidant vitamins are protective against colorectal cancer as well as human cancers in general, but epidemiological evidence is inconclusive. We investigated associations of dietary intakes of retinol and antioxidant vitamins with colorectal cancer risk in 816 incident cases of histologically confirmed colorectal cancer and 815 controls randomly selected for the Fukuoka colorectal cancer study in Japan. Dietary intakes were assessed by a PC-assisted interview regarding 148 food items. Statistical adjustment was made for body mass index, physical activity, calcium, and n-3 fatty acid intake and other factors. Retinol intake was significantly, inversely associated with colorectal cancer risk; the odds ratio for the highest vs. lowest was 0.55 (95% CI: 0.35, 0.88; Ptrend = 0.01) in women, but a modest increase in the risk was observed among men with the highest intake of retinol. Liver was the major source of retinol intake and showed similar associations with colorectal cancer risk in men and women. Intake of carotenes, vitamin C, and vitamin E were not related to colorectal cancer risk in either men or women. The study did not support a hypothesis that dietary intake of antioxidant vitamins is protective in the development of colorectal cancer.
AB - It has long been a matter of interest whether antioxidant vitamins are protective against colorectal cancer as well as human cancers in general, but epidemiological evidence is inconclusive. We investigated associations of dietary intakes of retinol and antioxidant vitamins with colorectal cancer risk in 816 incident cases of histologically confirmed colorectal cancer and 815 controls randomly selected for the Fukuoka colorectal cancer study in Japan. Dietary intakes were assessed by a PC-assisted interview regarding 148 food items. Statistical adjustment was made for body mass index, physical activity, calcium, and n-3 fatty acid intake and other factors. Retinol intake was significantly, inversely associated with colorectal cancer risk; the odds ratio for the highest vs. lowest was 0.55 (95% CI: 0.35, 0.88; Ptrend = 0.01) in women, but a modest increase in the risk was observed among men with the highest intake of retinol. Liver was the major source of retinol intake and showed similar associations with colorectal cancer risk in men and women. Intake of carotenes, vitamin C, and vitamin E were not related to colorectal cancer risk in either men or women. The study did not support a hypothesis that dietary intake of antioxidant vitamins is protective in the development of colorectal cancer.
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U2 - 10.1080/01635581.2012.690927
DO - 10.1080/01635581.2012.690927
M3 - Article
C2 - 22716281
AN - SCOPUS:84865232649
SN - 0163-5581
VL - 64
SP - 798
EP - 805
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 6
ER -
