Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats

Masao Sato, Takatoshi Ueda, Kazuko Nagata, Sawako Shiratake, Hiroko Tomoyori, Mitsuo Kawakami, Yukio Ozaki, Hiroshi Okubo, Bungo Shirouchi, Katsumi Imaizumi

Research output: Contribution to journalArticle

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Abstract

Kakrol (Momordica dioica Roxb.) is a cucurbitaceous vegetable native to India and Bangladesh. Bitter gourd (Momordica charantia Linn.), a species related to kakrol, has been shown to have pharmacological properties including antidiabetic and antisteatotic effects. In this study, we investigated the effect of dietary kakrol on lipid metabolism in rats. Sprague-Dawley rats were fed AIN-76 formula diets containing 3% freeze-dried powders of whole kakrol or bitter gourd for two weeks. Results showed significantly lowered liver cholesterol and triacylglycerol levels in rats fed on both diets. Fecal lipid excretion increased in rats fed the kakrol diet, and lymphatic transport of triacylglycerol and phospholipids decreased in rats fed the kakrol diet after permanent lymph cannulation. Furthermore, n-butanol extract from kakrol caused a significant concentration-dependent decrease in the pancreatic lipase activity in vitro. These results indicate that the mechanisms of action on lipid metabolism in kakrol and bitter gourd are different and that dietary kakrol reduces liver lipids by inhibiting lipid absorption.

Original languageEnglish
Pages (from-to)1139-1146
Number of pages8
JournalExperimental Biology and Medicine
Volume236
Issue number10
DOIs
Publication statusPublished - Oct 1 2011

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Momordica
Momordica charantia
Fatty Liver
Liver
Rats
Nutrition
Triglycerides
Diet
Lipids
Lipid Metabolism
Formulated Food
1-Butanol
Bangladesh
Lymph
Lipase
Hypoglycemic Agents
Catheterization
Vegetables
Powders
Sprague Dawley Rats

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats. / Sato, Masao; Ueda, Takatoshi; Nagata, Kazuko; Shiratake, Sawako; Tomoyori, Hiroko; Kawakami, Mitsuo; Ozaki, Yukio; Okubo, Hiroshi; Shirouchi, Bungo; Imaizumi, Katsumi.

In: Experimental Biology and Medicine, Vol. 236, No. 10, 01.10.2011, p. 1139-1146.

Research output: Contribution to journalArticle

Sato, Masao ; Ueda, Takatoshi ; Nagata, Kazuko ; Shiratake, Sawako ; Tomoyori, Hiroko ; Kawakami, Mitsuo ; Ozaki, Yukio ; Okubo, Hiroshi ; Shirouchi, Bungo ; Imaizumi, Katsumi. / Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats. In: Experimental Biology and Medicine. 2011 ; Vol. 236, No. 10. pp. 1139-1146.
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AU - Shiratake, Sawako

AU - Tomoyori, Hiroko

AU - Kawakami, Mitsuo

AU - Ozaki, Yukio

AU - Okubo, Hiroshi

AU - Shirouchi, Bungo

AU - Imaizumi, Katsumi

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