Dietary manipulations of body fat-reducing potential of conjugated linoleic acid in rats

Michihiro Sugano, Asuka Akahoshi, Kazunori Koba, Kazunari Tanaka, Tomoka Okumura, Hiroko Matsuyama, Yuki Goto, Tomoko Miyazaki, Kayoko Murao, Masao Yamasaki, Michiko Nonaka, Koji Yamada

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Abstract

To study whether the body fat-reducing potential of conjugated linoleic acid (CLA) could be increased through dietary manipulations, the effects of the combination of CLA with different proteins, fats, and sesamin were examined in rats. Male rats were fed diets containing 1% CLA or linoleic acid (LA) in combination with different proteins (20% of casein or soybean protein), fats (7% perilla oil or soybean oil) and 0.2% sesamin (SES) for 3 or 4 weeks. When the dietary fat source was soybean oil, CLA, as compared with LA, significantly reduced weights of epididymal and perirenal adipose tissues, irrespective of the dietary protein sources. However, the highest reducing effect was shown when soybean protein was given as a protein source. SES stimulated the reduction of epididymal and perirenal adipose tissue weights in both protein diets. In contrast, CLA increased the weight of brown adipose tissue, and SES further increased it in combination with soybean oil but not with perilla oil. No effect of dietary manipulation was observed on serum leptin and TNF-α levels. Thus, the body fat-reducing potential of CLA can be increased by an appropriate combination with food factors that may stimulate fatty acid β-oxidation.

Original languageEnglish
Pages (from-to)2535-2541
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume65
Issue number11
DOIs
Publication statusPublished - Nov 1 2001

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Sugano, M., Akahoshi, A., Koba, K., Tanaka, K., Okumura, T., Matsuyama, H., ... Yamada, K. (2001). Dietary manipulations of body fat-reducing potential of conjugated linoleic acid in rats. Bioscience, Biotechnology and Biochemistry, 65(11), 2535-2541. https://doi.org/10.1271/bbb.65.2535