Dietary patterns and risk of Parkinson's disease

A case-control study in Japan

H. Okubo, Y. Miyake, S. Sasaki, K. Murakami, K. Tanaka, W. Fukushima, Chikako Kiyohara, Y. Tsuboi, T. Yamada, T. Oeda, H. Shimada, N. Kawamura, N. Sakae, H. Fukuyama, Y. Hirota, M. Nagai

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Nearly all epidemiologic studies examining the association between the risk of Parkinson's disease (PD) and diet have focused on single foods and specific nutrients. However, epidemiologic evidence for the association of dietary pattern with PD, namely the measurement of overall diet by considering the cumulative effects of nutrients is extremely limited. We conducted a hospital-based case-control study in Japan to examine the relationship between dietary patterns and the risk of PD. Methods: Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n=249) and controls without neurodegenerative diseases (n=368) were recruited. At the time of recruitment, dietary intake during the preceding 1month was assessed using a validated, self-administered diet history questionnaire. Dietary patterns from 33 predefined food groups (energy-adjusted food g/day) were extracted by factor analysis. Results: Three dietary patterns were identified: 'Healthy', 'Western' and 'Light meal' patterns. After adjustment for potential non-dietary confounding factors, the Healthy pattern, characterized by a high intake of vegetables, seaweed, pulses, mushrooms, fruits and fish, was inversely associated with the risk of PD with a border-line significance (P for trend=0.06). Multivariate Odds ratio (95% confidence intervals) for PD in the highest quartile of the Healthy pattern was 0.54 (0.32-0.92) compared with the lowest quartile. No associations with PD were detected for the other two dietary patterns. Conclusion: In this case-control study in Japan, a dietary pattern consisting of high intakes of vegetables, fruits and fish may be associated with a decreased risk of PD.

Original languageEnglish
Pages (from-to)681-688
Number of pages8
JournalEuropean Journal of Neurology
Volume19
Issue number5
DOIs
Publication statusPublished - May 1 2012

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Parkinson Disease
Case-Control Studies
Japan
Food
Diet
Vegetables
Fruit
Fishes
Seaweed
Agaricales
Neurodegenerative Diseases
Statistical Factor Analysis
Meals
Epidemiologic Studies
Odds Ratio
Confidence Intervals
Light
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Okubo, H., Miyake, Y., Sasaki, S., Murakami, K., Tanaka, K., Fukushima, W., ... Nagai, M. (2012). Dietary patterns and risk of Parkinson's disease: A case-control study in Japan. European Journal of Neurology, 19(5), 681-688. https://doi.org/10.1111/j.1468-1331.2011.03600.x

Dietary patterns and risk of Parkinson's disease : A case-control study in Japan. / Okubo, H.; Miyake, Y.; Sasaki, S.; Murakami, K.; Tanaka, K.; Fukushima, W.; Kiyohara, Chikako; Tsuboi, Y.; Yamada, T.; Oeda, T.; Shimada, H.; Kawamura, N.; Sakae, N.; Fukuyama, H.; Hirota, Y.; Nagai, M.

In: European Journal of Neurology, Vol. 19, No. 5, 01.05.2012, p. 681-688.

Research output: Contribution to journalArticle

Okubo, H, Miyake, Y, Sasaki, S, Murakami, K, Tanaka, K, Fukushima, W, Kiyohara, C, Tsuboi, Y, Yamada, T, Oeda, T, Shimada, H, Kawamura, N, Sakae, N, Fukuyama, H, Hirota, Y & Nagai, M 2012, 'Dietary patterns and risk of Parkinson's disease: A case-control study in Japan', European Journal of Neurology, vol. 19, no. 5, pp. 681-688. https://doi.org/10.1111/j.1468-1331.2011.03600.x
Okubo, H. ; Miyake, Y. ; Sasaki, S. ; Murakami, K. ; Tanaka, K. ; Fukushima, W. ; Kiyohara, Chikako ; Tsuboi, Y. ; Yamada, T. ; Oeda, T. ; Shimada, H. ; Kawamura, N. ; Sakae, N. ; Fukuyama, H. ; Hirota, Y. ; Nagai, M. / Dietary patterns and risk of Parkinson's disease : A case-control study in Japan. In: European Journal of Neurology. 2012 ; Vol. 19, No. 5. pp. 681-688.
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T2 - A case-control study in Japan

AU - Okubo, H.

AU - Miyake, Y.

AU - Sasaki, S.

AU - Murakami, K.

AU - Tanaka, K.

AU - Fukushima, W.

AU - Kiyohara, Chikako

AU - Tsuboi, Y.

AU - Yamada, T.

AU - Oeda, T.

AU - Shimada, H.

AU - Kawamura, N.

AU - Sakae, N.

AU - Fukuyama, H.

AU - Hirota, Y.

AU - Nagai, M.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Background: Nearly all epidemiologic studies examining the association between the risk of Parkinson's disease (PD) and diet have focused on single foods and specific nutrients. However, epidemiologic evidence for the association of dietary pattern with PD, namely the measurement of overall diet by considering the cumulative effects of nutrients is extremely limited. We conducted a hospital-based case-control study in Japan to examine the relationship between dietary patterns and the risk of PD. Methods: Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n=249) and controls without neurodegenerative diseases (n=368) were recruited. At the time of recruitment, dietary intake during the preceding 1month was assessed using a validated, self-administered diet history questionnaire. Dietary patterns from 33 predefined food groups (energy-adjusted food g/day) were extracted by factor analysis. Results: Three dietary patterns were identified: 'Healthy', 'Western' and 'Light meal' patterns. After adjustment for potential non-dietary confounding factors, the Healthy pattern, characterized by a high intake of vegetables, seaweed, pulses, mushrooms, fruits and fish, was inversely associated with the risk of PD with a border-line significance (P for trend=0.06). Multivariate Odds ratio (95% confidence intervals) for PD in the highest quartile of the Healthy pattern was 0.54 (0.32-0.92) compared with the lowest quartile. No associations with PD were detected for the other two dietary patterns. Conclusion: In this case-control study in Japan, a dietary pattern consisting of high intakes of vegetables, fruits and fish may be associated with a decreased risk of PD.

AB - Background: Nearly all epidemiologic studies examining the association between the risk of Parkinson's disease (PD) and diet have focused on single foods and specific nutrients. However, epidemiologic evidence for the association of dietary pattern with PD, namely the measurement of overall diet by considering the cumulative effects of nutrients is extremely limited. We conducted a hospital-based case-control study in Japan to examine the relationship between dietary patterns and the risk of PD. Methods: Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n=249) and controls without neurodegenerative diseases (n=368) were recruited. At the time of recruitment, dietary intake during the preceding 1month was assessed using a validated, self-administered diet history questionnaire. Dietary patterns from 33 predefined food groups (energy-adjusted food g/day) were extracted by factor analysis. Results: Three dietary patterns were identified: 'Healthy', 'Western' and 'Light meal' patterns. After adjustment for potential non-dietary confounding factors, the Healthy pattern, characterized by a high intake of vegetables, seaweed, pulses, mushrooms, fruits and fish, was inversely associated with the risk of PD with a border-line significance (P for trend=0.06). Multivariate Odds ratio (95% confidence intervals) for PD in the highest quartile of the Healthy pattern was 0.54 (0.32-0.92) compared with the lowest quartile. No associations with PD were detected for the other two dietary patterns. Conclusion: In this case-control study in Japan, a dietary pattern consisting of high intakes of vegetables, fruits and fish may be associated with a decreased risk of PD.

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JO - European Journal of Neurology

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