Dietary sorbose prevents and improves hyperglycemia in genetically diabetic mice

Mitsuhiro Furuse, C. Kimura, R. T. Mabayo, H. Takahashi, J. I. Okumura

Research output: Contribution to journalArticle

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Abstract

The effect of dietary sorbose on the prevention (Experiment 1) and amelioration (Experiment 2) of diabetes was investigated in the genetically diabetic mouse [C57BL/KsJ (db/db)] for 6 wk. When sucrose (200 g/kg diet) in a control diet was replaced by sorbose, the blood glucose concentration was dramatically lower, but the serum insulin concentrations did not differ. When mice were fed the diets before the onset of diabetic symptoms, glucose excretion in urine was prevented in the mice fed the sorbose diet, but mice fed the control diet excreted glucose in the urine, and the concentration increased with age. When dietary treatment began after the development of diabetic symptoms, dietary sorbose greatly reduced the incidence of hyperglycemia and lowered urinary glucose excretion, compared with mice fed the sucrose-containing diet. These results suggest that dietary sorbose might be useful in patients with, or at risk of developing, noninsulin-dependent diabetes, both before and after exhibiting the syndrome.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalJournal of Nutrition
Volume123
Issue number1
Publication statusPublished - Jan 1 1993

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Sorbose
Hyperglycemia
Diet
Glucose
Sucrose
Urine
Inbred C57BL Mouse
Blood Glucose
Insulin
Incidence
Serum

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Furuse, M., Kimura, C., Mabayo, R. T., Takahashi, H., & Okumura, J. I. (1993). Dietary sorbose prevents and improves hyperglycemia in genetically diabetic mice. Journal of Nutrition, 123(1), 59-65.

Dietary sorbose prevents and improves hyperglycemia in genetically diabetic mice. / Furuse, Mitsuhiro; Kimura, C.; Mabayo, R. T.; Takahashi, H.; Okumura, J. I.

In: Journal of Nutrition, Vol. 123, No. 1, 01.01.1993, p. 59-65.

Research output: Contribution to journalArticle

Furuse, M, Kimura, C, Mabayo, RT, Takahashi, H & Okumura, JI 1993, 'Dietary sorbose prevents and improves hyperglycemia in genetically diabetic mice', Journal of Nutrition, vol. 123, no. 1, pp. 59-65.
Furuse M, Kimura C, Mabayo RT, Takahashi H, Okumura JI. Dietary sorbose prevents and improves hyperglycemia in genetically diabetic mice. Journal of Nutrition. 1993 Jan 1;123(1):59-65.
Furuse, Mitsuhiro ; Kimura, C. ; Mabayo, R. T. ; Takahashi, H. ; Okumura, J. I. / Dietary sorbose prevents and improves hyperglycemia in genetically diabetic mice. In: Journal of Nutrition. 1993 ; Vol. 123, No. 1. pp. 59-65.
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