Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats

Ikuo Ikeda, Mariko Kudo, Tadateru Hamada, Koji Nagao, Yoko Oshiro, Masaki Kato, Takashi Sugawara, Takashi Yamahira, Hiroko Ito, Shogo Tamaru, Masao Sato, Katsumi Imaizumi, Satoshi Nagaoka, Teruyoshi Y. Anagita

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS. Hepatic expression of ATP-binding cassette transporter G5 (ABCG5) and ATP-binding cassette transporter G8 (ABCG8) mRNA was significantly higher in rats fed SPI and HMF than in those fed CAS. These observations suggest that increased biliary excretion of cholesterol in SPI and HMF groups is caused by the enhanced expression of Abcg5/Abcg8.

Original languageEnglish
Pages (from-to)252-256
Number of pages5
JournalJournal of Nutritional Science and Vitaminology
Volume55
Issue number3
DOIs
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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