Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population: The Hisayama Study

Masashi Miyazaki, Yasufumi Doi, Fumie Ikeda, Toshiharu Ninomiya, Jun Hata, Kazuhiro Uchida, Tomoko Shirota, Takayuki Matsumoto, Mitsuo Iida, Yutaka Kiyohara

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Abstract

Background The results of prospective studies examining the association between dietary vitamin A intake and the risk of gastric cancer have often been conflicting. The objective of this study was to investigate this issue in a general Japanese population. Methods A total of 2,467 community-dwelling Japanese subjects aged 40 years or older were followed up prospectively for 14 years. Dietary vitamin A intake was estimated using a semiquantitative food frequency method. Results During the follow-up period, gastric cancer developed in 93 subjects. The age- and sex-adjusted incidence of gastric cancer rose progressively with increasing levels of dietary vitamin A intake: at 2.2, 3.0, 3.8, and 4.5 per 1,000 person-years for quartile groups defined by dietary vitamin A intake levels of <639, 639-837, 838-1,061, and >1,061 μg retinol equivalents (RE)/day, respectively (P for trend < 0.01). The risk of gastric cancer was significantly higher in the fourth quartile than in the first one even after multivariate adjustment [hazard ratio (HR) = 1.47, 95% confidence interval (CI) = 0.70-3.09, P = 0.30 for the second quartile; HR = 1.85, 95% CI = 0.82-4.18, P = 0.14 for the third quartile; HR = 2.96, 95% CI = 1.12-7.80, P = 0.03 for the fourth quartile]. Comparable effects of vitamin A intake were observed irrespective of the location or histological type of gastric cancer. The HR for gastric cancer increased significantly only in subjects with a combination of high vitamin A intake (>1,061 μg RE/day) and Helicobacter pylori infection. Conclusions Our findings suggest that dietary vitamin A intake is clearly associated with the risk of gastric cancer in the general Japanese population.

Original languageEnglish
Pages (from-to)162-169
Number of pages8
JournalGastric Cancer
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 1 2012

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Vitamin A
Stomach Neoplasms
Incidence
Population
Independent Living
Helicobacter Infections
Helicobacter pylori
Prospective Studies
Food

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology
  • Cancer Research

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Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population : The Hisayama Study. / Miyazaki, Masashi; Doi, Yasufumi; Ikeda, Fumie; Ninomiya, Toshiharu; Hata, Jun; Uchida, Kazuhiro; Shirota, Tomoko; Matsumoto, Takayuki; Iida, Mitsuo; Kiyohara, Yutaka.

In: Gastric Cancer, Vol. 15, No. 2, 01.04.2012, p. 162-169.

Research output: Contribution to journalArticle

Miyazaki, M, Doi, Y, Ikeda, F, Ninomiya, T, Hata, J, Uchida, K, Shirota, T, Matsumoto, T, Iida, M & Kiyohara, Y 2012, 'Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population: The Hisayama Study', Gastric Cancer, vol. 15, no. 2, pp. 162-169. https://doi.org/10.1007/s10120-011-0092-7
Miyazaki, Masashi ; Doi, Yasufumi ; Ikeda, Fumie ; Ninomiya, Toshiharu ; Hata, Jun ; Uchida, Kazuhiro ; Shirota, Tomoko ; Matsumoto, Takayuki ; Iida, Mitsuo ; Kiyohara, Yutaka. / Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population : The Hisayama Study. In: Gastric Cancer. 2012 ; Vol. 15, No. 2. pp. 162-169.
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abstract = "Background The results of prospective studies examining the association between dietary vitamin A intake and the risk of gastric cancer have often been conflicting. The objective of this study was to investigate this issue in a general Japanese population. Methods A total of 2,467 community-dwelling Japanese subjects aged 40 years or older were followed up prospectively for 14 years. Dietary vitamin A intake was estimated using a semiquantitative food frequency method. Results During the follow-up period, gastric cancer developed in 93 subjects. The age- and sex-adjusted incidence of gastric cancer rose progressively with increasing levels of dietary vitamin A intake: at 2.2, 3.0, 3.8, and 4.5 per 1,000 person-years for quartile groups defined by dietary vitamin A intake levels of <639, 639-837, 838-1,061, and >1,061 μg retinol equivalents (RE)/day, respectively (P for trend < 0.01). The risk of gastric cancer was significantly higher in the fourth quartile than in the first one even after multivariate adjustment [hazard ratio (HR) = 1.47, 95{\%} confidence interval (CI) = 0.70-3.09, P = 0.30 for the second quartile; HR = 1.85, 95{\%} CI = 0.82-4.18, P = 0.14 for the third quartile; HR = 2.96, 95{\%} CI = 1.12-7.80, P = 0.03 for the fourth quartile]. Comparable effects of vitamin A intake were observed irrespective of the location or histological type of gastric cancer. The HR for gastric cancer increased significantly only in subjects with a combination of high vitamin A intake (>1,061 μg RE/day) and Helicobacter pylori infection. Conclusions Our findings suggest that dietary vitamin A intake is clearly associated with the risk of gastric cancer in the general Japanese population.",
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T2 - The Hisayama Study

AU - Miyazaki, Masashi

AU - Doi, Yasufumi

AU - Ikeda, Fumie

AU - Ninomiya, Toshiharu

AU - Hata, Jun

AU - Uchida, Kazuhiro

AU - Shirota, Tomoko

AU - Matsumoto, Takayuki

AU - Iida, Mitsuo

AU - Kiyohara, Yutaka

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AB - Background The results of prospective studies examining the association between dietary vitamin A intake and the risk of gastric cancer have often been conflicting. The objective of this study was to investigate this issue in a general Japanese population. Methods A total of 2,467 community-dwelling Japanese subjects aged 40 years or older were followed up prospectively for 14 years. Dietary vitamin A intake was estimated using a semiquantitative food frequency method. Results During the follow-up period, gastric cancer developed in 93 subjects. The age- and sex-adjusted incidence of gastric cancer rose progressively with increasing levels of dietary vitamin A intake: at 2.2, 3.0, 3.8, and 4.5 per 1,000 person-years for quartile groups defined by dietary vitamin A intake levels of <639, 639-837, 838-1,061, and >1,061 μg retinol equivalents (RE)/day, respectively (P for trend < 0.01). The risk of gastric cancer was significantly higher in the fourth quartile than in the first one even after multivariate adjustment [hazard ratio (HR) = 1.47, 95% confidence interval (CI) = 0.70-3.09, P = 0.30 for the second quartile; HR = 1.85, 95% CI = 0.82-4.18, P = 0.14 for the third quartile; HR = 2.96, 95% CI = 1.12-7.80, P = 0.03 for the fourth quartile]. Comparable effects of vitamin A intake were observed irrespective of the location or histological type of gastric cancer. The HR for gastric cancer increased significantly only in subjects with a combination of high vitamin A intake (>1,061 μg RE/day) and Helicobacter pylori infection. Conclusions Our findings suggest that dietary vitamin A intake is clearly associated with the risk of gastric cancer in the general Japanese population.

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