Difference between substance P- and acetylcholine-induced currents in mammalian smooth muscle cells

Ken Nakazawa, Kazuhide Inoue, Kannosuke Fujimori, Akira Takanaka

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effects of substance P (SP) and acetylcholine (ACh) on membrane currents were compared using freshly isolated smooth muscle cells from guinea-pig ileum. Both SP (100 nM) and ACh (10μM) induced inward currents at negative holding potentials. The ACh-induced current, but not the SP-induced current, showed relaxation upon voltage-stepping. The SP-induced current was increased by hyperpolarization more negative than -50 mV whereas the ACh-induced current was decreased by hyperpolarization. The results suggest that the SP-induced inward current is elicited via an ionic pathway different from that involved with ACh-activated channels.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalEuropean Journal of Pharmacology
Volume179
Issue number3
DOIs
Publication statusPublished - Apr 25 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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