Difference in B cell activation between dermatomyositis and polymyositis: Analysis of the expression of RP105 on peripheral blood B cells

Y. Kikuchi, S. Koarada, Y. Tada, O. Ushiyam, F. Morito, N. Suzuki, A. Ohta, T. Horiuchi, K. Miyake, K. Nagasawa

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background - It has previously been shown that RP105, a new B cell surface protein, is lost in activated human B cells. Objective - To investigate whether there is a difference in B cell activation between patients with dermatomyositis (DM) and those with polymyositis (PM) using RP105 as a marker. Methods - The population of RP105 negative B cells (activated B cells) in the peripheral blood mononuclear cells of seven patients with dermatomyositis (DM) and 11 with polymyositis (PM) was analysed by flow cytometry. Results - The percentage of RP105 negative B cells in the peripheral blood of patients with PM was low (5.8 (SD 2.4)%), similar to that of normal subjects. In contrast, all patients with DM showed increased RP105 negative B cell populations (33.0 (6.9)%). Bronchoalveolar lavage fluid from a patient with DM and active interstitial pneumonitis contained a large number of RP105 negative B cells. Conclusion - These findings suggest that the expansion of RP105 negative B cells is a hallmark of DM, and that B cell activation in DM may be pathogenetically different from that in PM.

Original languageEnglish
Pages (from-to)1137-1140
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume60
Issue number12
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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