TY - JOUR
T1 - Difference in B cell activation between dermatomyositis and polymyositis
T2 - Analysis of the expression of RP105 on peripheral blood B cells
AU - Kikuchi, Y.
AU - Koarada, S.
AU - Tada, Y.
AU - Ushiyam, O.
AU - Morito, F.
AU - Suzuki, N.
AU - Ohta, A.
AU - Horiuchi, T.
AU - Miyake, K.
AU - Nagasawa, K.
PY - 2001
Y1 - 2001
N2 - Background - It has previously been shown that RP105, a new B cell surface protein, is lost in activated human B cells. Objective - To investigate whether there is a difference in B cell activation between patients with dermatomyositis (DM) and those with polymyositis (PM) using RP105 as a marker. Methods - The population of RP105 negative B cells (activated B cells) in the peripheral blood mononuclear cells of seven patients with dermatomyositis (DM) and 11 with polymyositis (PM) was analysed by flow cytometry. Results - The percentage of RP105 negative B cells in the peripheral blood of patients with PM was low (5.8 (SD 2.4)%), similar to that of normal subjects. In contrast, all patients with DM showed increased RP105 negative B cell populations (33.0 (6.9)%). Bronchoalveolar lavage fluid from a patient with DM and active interstitial pneumonitis contained a large number of RP105 negative B cells. Conclusion - These findings suggest that the expansion of RP105 negative B cells is a hallmark of DM, and that B cell activation in DM may be pathogenetically different from that in PM.
AB - Background - It has previously been shown that RP105, a new B cell surface protein, is lost in activated human B cells. Objective - To investigate whether there is a difference in B cell activation between patients with dermatomyositis (DM) and those with polymyositis (PM) using RP105 as a marker. Methods - The population of RP105 negative B cells (activated B cells) in the peripheral blood mononuclear cells of seven patients with dermatomyositis (DM) and 11 with polymyositis (PM) was analysed by flow cytometry. Results - The percentage of RP105 negative B cells in the peripheral blood of patients with PM was low (5.8 (SD 2.4)%), similar to that of normal subjects. In contrast, all patients with DM showed increased RP105 negative B cell populations (33.0 (6.9)%). Bronchoalveolar lavage fluid from a patient with DM and active interstitial pneumonitis contained a large number of RP105 negative B cells. Conclusion - These findings suggest that the expansion of RP105 negative B cells is a hallmark of DM, and that B cell activation in DM may be pathogenetically different from that in PM.
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U2 - 10.1136/ard.60.12.1137
DO - 10.1136/ard.60.12.1137
M3 - Article
C2 - 11709456
AN - SCOPUS:0035189519
VL - 60
SP - 1137
EP - 1140
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 12
ER -