Difference of regional cerebral metabolic pattern between presenile and senile dementia of the Alzheimer type: A factor analytic study

Atsushi Ichimiya, Karl Herholz, Ruediger Mielke, Josef Kessler, Ina Slansky, Wolf Dieter Heiss

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Positron emission tomographic studies using metabolic ratios to represent the contrast between certain brain regions have shown differences of cerebral glucose metabolism between presenile and senile dementia of Alzheimer type (DAT). In this study, factors for regional variance of cerebral metabolism in 61 patients with probable Alzheimer's disease were obtained using principal component analysis (PCA). The difference between two age groups of DAT patients according to age at onset ≤ 65 years (n = 30) and > 65 years (n = 31) were investigated. A PCA using nine pairs of cerebral regions normalized to cerebellum for reduction of intersubject variability identified five regional factors for cerebral metabolism: one each for the left and right temporo-parietal cortex, and the other three for frontal cortex, primary visual and sensorimotor cortex, and mesial temporal cortex. The age groups differed significantly only in the factor for the right temporo-parietal cortex, with a more prominent metabolic reduction in presenile than senile DAT. Severity of dementia was correlated with the factors for the right and left temporo-parietal cortex. The effect of age at onset on glucose metabolism of the right temporo-parietal cortex was independent from that of dementia severity in DAT.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalJournal of the Neurological Sciences
Volume123
Issue number1-2
DOIs
Publication statusPublished - Jan 1 1994

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Parietal Lobe
Alzheimer Disease
Principal Component Analysis
Age of Onset
Dementia
Age Groups
Glucose
Frontal Lobe
Visual Cortex
Temporal Lobe
Cerebellum
Presenile And Senile Dementia
Electrons
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Difference of regional cerebral metabolic pattern between presenile and senile dementia of the Alzheimer type : A factor analytic study. / Ichimiya, Atsushi; Herholz, Karl; Mielke, Ruediger; Kessler, Josef; Slansky, Ina; Heiss, Wolf Dieter.

In: Journal of the Neurological Sciences, Vol. 123, No. 1-2, 01.01.1994, p. 11-17.

Research output: Contribution to journalArticle

Ichimiya, Atsushi ; Herholz, Karl ; Mielke, Ruediger ; Kessler, Josef ; Slansky, Ina ; Heiss, Wolf Dieter. / Difference of regional cerebral metabolic pattern between presenile and senile dementia of the Alzheimer type : A factor analytic study. In: Journal of the Neurological Sciences. 1994 ; Vol. 123, No. 1-2. pp. 11-17.
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