TY - JOUR
T1 - Differences in Candida albicans adhesion to intact and denatured type I collagen in vitro
AU - Makihira, S.
AU - Nikawa, H.
AU - Tamagami, M.
AU - Hamada, T.
AU - Samaranayake, L. P.
PY - 2002
Y1 - 2002
N2 - An inhibition assay of Candida albicans adhesion to gelatin-immobilized membranes was compared with that to intact type I collagen-immobilized membranes using an arginine-glycine-aspartic acid (RGD) containing peptide. As compared with a protein-free membrane, gelatin and collagen significantly enhanced the adherence of C albicans. The adhesion of the yeast to gelatin was significantly inhibited by the RGD peptides, but not by arginine-glycine-glutamic acid (RGE) peptides. In contrast, attachment to collagen was not inhibited by RGD peptides. These results suggest that the RGD sequence of gelatin and the integrin-like proteins of yeasts may be involved in adherence.
AB - An inhibition assay of Candida albicans adhesion to gelatin-immobilized membranes was compared with that to intact type I collagen-immobilized membranes using an arginine-glycine-aspartic acid (RGD) containing peptide. As compared with a protein-free membrane, gelatin and collagen significantly enhanced the adherence of C albicans. The adhesion of the yeast to gelatin was significantly inhibited by the RGD peptides, but not by arginine-glycine-glutamic acid (RGE) peptides. In contrast, attachment to collagen was not inhibited by RGD peptides. These results suggest that the RGD sequence of gelatin and the integrin-like proteins of yeasts may be involved in adherence.
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U2 - 10.1046/j.0902-0055.2001.00094.x
DO - 10.1046/j.0902-0055.2001.00094.x
M3 - Article
C2 - 11929562
AN - SCOPUS:0036010894
VL - 17
SP - 129
EP - 131
JO - Molecular Oral Microbiology
JF - Molecular Oral Microbiology
SN - 2041-1006
IS - 2
ER -