TY - JOUR
T1 - Differences in Clinical Characteristics between Patients with Transient Ischemic Attack Whose Symptoms Do and Do Not Persist on Arrival
AU - on behalf of the Japan TIA Research Group, 2009-2011
AU - Tanaka, Koji
AU - Uehara, Toshiyuki
AU - Kimura, Kazumi
AU - Okada, Yasushi
AU - Hasegawa, Yasuhiro
AU - Tanahashi, Norio
AU - Suzuki, Akifumi
AU - Takagi, Shigeharu
AU - Nakagawara, Jyoji
AU - Arii, Kazumasa
AU - Nagahiro, Shinji
AU - Ogasawara, Kuniaki
AU - Nagao, Takehiko
AU - Uchiyama, Shinichiro
AU - Matsumoto, Masayasu
AU - Iihara, Koji
AU - Toyoda, Kazunori
AU - Minematsu, Kazuo
N1 - Publisher Copyright:
© 2016 National Stroke Association
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background Symptoms of transient ischemic attack (TIA) persist on arrival and subsequently resolve in some patients admitted to hospitals early after onset. Differences in clinical characteristics between patients with acute TIA whose symptoms do and do not persist on arrival remain unclear. Methods We retrospectively extracted data of consecutive TIA patients with an onset-to-door time (ODT) of 24 hours or less and without a history of stroke from a multicenter TIA database. Clinical characteristics were compared between patients with and without persisting symptoms on arrival. Results Two hundred sixty-six patients (158 men, 68.0 ± 12.9 years) were included. Of the total number of patients, 105 (39.5%) had persisting symptoms with a mean National Institutes of Health Stroke Scale score of 2.4 (median, 1.0). Patients with persisting symptoms were more likely to have sensory disorder, ambulance-transported admission, long-duration TIA (≥60 minutes), and shorter ODT than those without. Multivariate analysis showed that sensory disorder (odds ratio [OR] 2.52, 95% confidence interval [CI] 1.35-4.77), ambulance-transported admission (OR 1.80, 95% CI 1.00-3.28), and long-duration TIA (OR 3.96, 95% CI 2.12-7.71) were positively associated and that an ODT of more than 12 hours (OR.18, 95% CI.04-.63) was inversely associated with the presence ofpersisting symptoms. Patients with persisting symptoms were more likely to be examined by a stroke physician at first (69% versus 57%, P = .049) and then hospitalized in a stroke unit (59% versus 43%, P = .010). Conclusion Clinical manifestations and management after admission might differ between patients with acute TIA whose symptoms do and do not persist on arrival.
AB - Background Symptoms of transient ischemic attack (TIA) persist on arrival and subsequently resolve in some patients admitted to hospitals early after onset. Differences in clinical characteristics between patients with acute TIA whose symptoms do and do not persist on arrival remain unclear. Methods We retrospectively extracted data of consecutive TIA patients with an onset-to-door time (ODT) of 24 hours or less and without a history of stroke from a multicenter TIA database. Clinical characteristics were compared between patients with and without persisting symptoms on arrival. Results Two hundred sixty-six patients (158 men, 68.0 ± 12.9 years) were included. Of the total number of patients, 105 (39.5%) had persisting symptoms with a mean National Institutes of Health Stroke Scale score of 2.4 (median, 1.0). Patients with persisting symptoms were more likely to have sensory disorder, ambulance-transported admission, long-duration TIA (≥60 minutes), and shorter ODT than those without. Multivariate analysis showed that sensory disorder (odds ratio [OR] 2.52, 95% confidence interval [CI] 1.35-4.77), ambulance-transported admission (OR 1.80, 95% CI 1.00-3.28), and long-duration TIA (OR 3.96, 95% CI 2.12-7.71) were positively associated and that an ODT of more than 12 hours (OR.18, 95% CI.04-.63) was inversely associated with the presence ofpersisting symptoms. Patients with persisting symptoms were more likely to be examined by a stroke physician at first (69% versus 57%, P = .049) and then hospitalized in a stroke unit (59% versus 43%, P = .010). Conclusion Clinical manifestations and management after admission might differ between patients with acute TIA whose symptoms do and do not persist on arrival.
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U2 - 10.1016/j.jstrokecerebrovasdis.2016.04.025
DO - 10.1016/j.jstrokecerebrovasdis.2016.04.025
M3 - Article
C2 - 27266623
AN - SCOPUS:84971645679
VL - 25
SP - 2237
EP - 2242
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
SN - 1052-3057
IS - 9
ER -