Differences in thymus dependency among the alloreactive T-cell subpopulations in their development

Hideyuki Kawauchi, Yoshinori Shimamoto, Kazuto Taniguchi, Chiharu Kubo, Kikuo Nomoto

Research output: Contribution to journalArticle

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Abstract

Effects of thymectomy at various times after birth (Tx-1, Tx-3, Tx-7, Tx-14) on mixed lymphocyte reaction (MLR), cell-mediated cytotoxicity (CMC), and graft-versus-host reaction (GVHR) were examined by experiments with spleen cells obtained at 8 weeks of age. All of MLR, CMC, and GVHR were detected in spleen cells of Tx-14 mice. However, the ability of spleen cells to induce GVHR was abolished by thymectomy at 7 days after birth. On the other hand, MLR and CMC were not affected in such mice. In Tx-1 or Tx-3 mice, only MLR was detected in spleen cells. These results suggest that thymus dependency of T cells responsible for MLR are lower in their maturation than those for CMC and that thymus dependency of T cells responsible for GVHR are the highest among these T-cell subpopulations.

Original languageEnglish
Pages (from-to)76-84
Number of pages9
JournalCellular Immunology
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 1 1982

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Thymus Gland
Mixed Lymphocyte Culture Test
T-Lymphocytes
Spleen
Transplants
Thymectomy
Parturition

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Differences in thymus dependency among the alloreactive T-cell subpopulations in their development. / Kawauchi, Hideyuki; Shimamoto, Yoshinori; Taniguchi, Kazuto; Kubo, Chiharu; Nomoto, Kikuo.

In: Cellular Immunology, Vol. 70, No. 1, 01.01.1982, p. 76-84.

Research output: Contribution to journalArticle

Kawauchi, Hideyuki ; Shimamoto, Yoshinori ; Taniguchi, Kazuto ; Kubo, Chiharu ; Nomoto, Kikuo. / Differences in thymus dependency among the alloreactive T-cell subpopulations in their development. In: Cellular Immunology. 1982 ; Vol. 70, No. 1. pp. 76-84.
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