Differences in thymus-dependency among various T-cell functions

Y. Shimamoto, K. Taniguchi, C. Kubo, K. Nomoto

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Effects of thymectomy at various times after birth on cytotoxicity, delayed footpad reaction and antibody production were examined in 6 week old mice immunized intraperitoneally with chicken erythrocytes. Cytotoxicity and antibody production were abolished by thymectomy within 3 days after birth. Mice thymectomized at 5 days of age or later showed appreciable degrees of cytotoxicity and antibody production. On the other hand, a delayed footpad reaction could be elicited even in mice thymectomized within 24 h after birth, although the degree of the reaction was reduced by such a treatment. Therefore, T cells responsible for delayed hypersensitivity were less thymus-dependent and required the presence of the thymus for a shorter period in their development that those responsible for cytotoxicity or antibody production.

Original languageEnglish
Pages (from-to)167-178
Number of pages12
JournalImmunology
Volume41
Issue number1
Publication statusPublished - Jan 1 1980

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Thymus Gland
Antibody Formation
T-Lymphocytes
Thymectomy
Parturition
Delayed Hypersensitivity
Chickens
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Shimamoto, Y., Taniguchi, K., Kubo, C., & Nomoto, K. (1980). Differences in thymus-dependency among various T-cell functions. Immunology, 41(1), 167-178.

Differences in thymus-dependency among various T-cell functions. / Shimamoto, Y.; Taniguchi, K.; Kubo, C.; Nomoto, K.

In: Immunology, Vol. 41, No. 1, 01.01.1980, p. 167-178.

Research output: Contribution to journalArticle

Shimamoto, Y, Taniguchi, K, Kubo, C & Nomoto, K 1980, 'Differences in thymus-dependency among various T-cell functions', Immunology, vol. 41, no. 1, pp. 167-178.
Shimamoto Y, Taniguchi K, Kubo C, Nomoto K. Differences in thymus-dependency among various T-cell functions. Immunology. 1980 Jan 1;41(1):167-178.
Shimamoto, Y. ; Taniguchi, K. ; Kubo, C. ; Nomoto, K. / Differences in thymus-dependency among various T-cell functions. In: Immunology. 1980 ; Vol. 41, No. 1. pp. 167-178.
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