Different circulating brain-derived neurotrophic factor responses to acute exercise between physically active and sedentary subjects

Yu Nofuji, Masataka Suwa, Haruka Sasaki, Atsushi Ichimiya, Reiko Nishichi, Shuzo Kumagai

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Although circulating brain-derived neurotrophic factor (BDNF) level is affected by both acute and chronic physical activity, the interaction of acute and chronic physical activity was still unclear. In this study, we compared the serum and plasma BDNF responses to maximal and submaximal acute exercises between physically active and sedentary subjects. Eight active and 8 sedentary female subjects participated in the present study. Both groups performed 3 exercise tests with different intensities, i.e. 100% (maximal), 60% (moderate) and 40% (low) of their peak oxygen uptake. In each exercise test, blood samples were taken at the baseline and immediately, 30 and 60 min after the test. The serum BDNF concentration was found to significantly increase immediately after maximal and moderate exercise tests in both groups. In maximal exercise test, the pattern of change in the serum BDNF concentration was different between the groups. While the serum BDNF level for the sedentary group returned to the baseline level during the recovery phase, the BDNF levels for the active group decreased below the baseline level after the maximal exercise test. No group differences were observed in the pattern of plasma BDNF change for all exercise tests. These findings suggest that regular exercise facilitates the utilization of circulating BDNF during and/or after acute exercise with maximal intensity.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalJournal of Sports Science and Medicine
Volume11
Issue number1
Publication statusPublished - Mar 1 2012

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Brain-Derived Neurotrophic Factor
Exercise Test
Exercise
Serum
Oxygen

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Different circulating brain-derived neurotrophic factor responses to acute exercise between physically active and sedentary subjects. / Nofuji, Yu; Suwa, Masataka; Sasaki, Haruka; Ichimiya, Atsushi; Nishichi, Reiko; Kumagai, Shuzo.

In: Journal of Sports Science and Medicine, Vol. 11, No. 1, 01.03.2012, p. 83-88.

Research output: Contribution to journalArticle

Nofuji, Yu ; Suwa, Masataka ; Sasaki, Haruka ; Ichimiya, Atsushi ; Nishichi, Reiko ; Kumagai, Shuzo. / Different circulating brain-derived neurotrophic factor responses to acute exercise between physically active and sedentary subjects. In: Journal of Sports Science and Medicine. 2012 ; Vol. 11, No. 1. pp. 83-88.
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