Different effects of cholinergic agents on responses recorded from the cat visual cortex and lateral geniculate nucleus dorsalis

Kenji Arakawa, Shozo Tobimatsu, Motohiro Kato, Takuro Kobayashi

Research output: Contribution to journalArticle

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Abstract

We investigated the effect of cholinergic agents on the cat visual evoked potentials (VEPs) recorded from the primary visual cortex (V1) and lateral geniculate nucleus dorsalis (LGNd) to determine on which level of the visual pathway the cholinergic system acts. VEPs to the alternation of 0.1 cycles per degree sinusoidal gratings at 1 and 4 Hz were recorded from N2O- anesthetized cats directly from the surface of V1 and LGNd. The depth of recording in LGNd was determined by the site where the maximal response was obtained by 1 Hz stimulation. VEPs to 4 Hz stimulation, which showed sinusoidal waveforms and were analyzed by fast Fourier transforms, were used as indicators for modulation by cholinergic agents. Physostigmine, an acetylcholinesterase inhibitor, 0.7 mg/kg i.v., suppressed the amplitude of the responses more at V1 (suppression ratio: mean ± SD, 85.4 ± 9.3%) than at LGNd (32.4. ± 30.7%) (P < 0.05). Conversely, scopolamine, a muscarinic receptor blocker, 0.7 mg/kg i.v., increased the amplitude of the responses more at V1 (enhancement ratio: mean ± SD, 60.3 ± 22.3%) than at LGNd (- 22.2 ± 22.5%) (P < 0.05). These results indicate that the V1 changes reflect a direct cortical cholinergic effect, probably by modulating the cholinergic projection from the nucleus basalis of Meynert to V1.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalElectroencephalography and Clinical Neurophysiology - Evoked Potentials
Volume104
Issue number4
DOIs
Publication statusPublished - Jul 1 1997

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Geniculate Bodies
Visual Cortex
Cholinergic Agents
Cats
Visual Evoked Potentials
Nijmegen Breakage Syndrome
Basal Nucleus of Meynert
Physostigmine
Visual Pathways
Scopolamine Hydrobromide
Cholinesterase Inhibitors
Muscarinic Receptors
Fourier Analysis
Spinal Cord Dorsal Horn

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology

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Different effects of cholinergic agents on responses recorded from the cat visual cortex and lateral geniculate nucleus dorsalis. / Arakawa, Kenji; Tobimatsu, Shozo; Kato, Motohiro; Kobayashi, Takuro.

In: Electroencephalography and Clinical Neurophysiology - Evoked Potentials, Vol. 104, No. 4, 01.07.1997, p. 375-380.

Research output: Contribution to journalArticle

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