Different Hormonal Expression Patterns between Primary Pancreatic Neuroendocrine Tumors and Metastatic Sites

Hideyo Kimura, Takao Ohtsuka, Takaaki Fujimoto, Kenjiro Date, Taketo Matsunaga, Ana Ines Cases, Atsushi Abe, Yusuke Mizuuchi, Yoshihiro Miyasaka, Tetsuhide Ito, Yoshinao Oda, Masafumi Nakamura, Masao Tanaka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives Pancreatic neuroendocrine tumors (PNETs) are known to have heterogeneity in terms of their ability to produce multiple hormones. The aim of this study was to evaluate the heterogeneity of PNETs from the viewpoint of hormonal expression. Methods The expressions of 4 representative hormones, gastrin, insulin, glucagon, and somatostatin, in both primary and metastatic lesions, were analyzed by immunohistochemical staining in 20 patients with metastatic PNETs (6 gastrinomas, 1 insulinoma, 1 glucagonoma, and 12 nonfunctioning PNETs [NF-PNETs]). Metastatic sites included lymph nodes in all 20 patients and liver metastasis in 7 patients (2 gastrinomas and 5 NF-PNETs). Results There were 6 PNETs with multiple hormone secretion (30%), and positive expression of 1 or more hormones was found in 9 of 12 patients whose primary tumors were diagnosed as NF-PNETs. The positive concordance rate of the hormonal expression pattern between primary tumors and metastatic lymph nodes and between primary tumors and hepatic metastasis were 50% and 11%, respectively. Three patients had metastatic lesions with positive hormonal expression, whereas their primary tumors were negative. Conclusions Hormonal expressions are often different between the primary tumors and metastatic sites of PNETs.

Original languageEnglish
Pages (from-to)947-952
Number of pages6
JournalPancreas
Volume45
Issue number7
DOIs
Publication statusPublished - Aug 1 2016

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Neuroendocrine Tumors
Hormones
Gastrinoma
Primitive Neuroectodermal Tumors
Neoplasms
Lymph Nodes
Glucagonoma
Neoplasm Metastasis
Insulinoma
Liver
Gastrins
Somatostatin
Glucagon
Insulin
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Different Hormonal Expression Patterns between Primary Pancreatic Neuroendocrine Tumors and Metastatic Sites. / Kimura, Hideyo; Ohtsuka, Takao; Fujimoto, Takaaki; Date, Kenjiro; Matsunaga, Taketo; Cases, Ana Ines; Abe, Atsushi; Mizuuchi, Yusuke; Miyasaka, Yoshihiro; Ito, Tetsuhide; Oda, Yoshinao; Nakamura, Masafumi; Tanaka, Masao.

In: Pancreas, Vol. 45, No. 7, 01.08.2016, p. 947-952.

Research output: Contribution to journalArticle

Kimura, H, Ohtsuka, T, Fujimoto, T, Date, K, Matsunaga, T, Cases, AI, Abe, A, Mizuuchi, Y, Miyasaka, Y, Ito, T, Oda, Y, Nakamura, M & Tanaka, M 2016, 'Different Hormonal Expression Patterns between Primary Pancreatic Neuroendocrine Tumors and Metastatic Sites', Pancreas, vol. 45, no. 7, pp. 947-952. https://doi.org/10.1097/MPA.0000000000000570
Kimura, Hideyo ; Ohtsuka, Takao ; Fujimoto, Takaaki ; Date, Kenjiro ; Matsunaga, Taketo ; Cases, Ana Ines ; Abe, Atsushi ; Mizuuchi, Yusuke ; Miyasaka, Yoshihiro ; Ito, Tetsuhide ; Oda, Yoshinao ; Nakamura, Masafumi ; Tanaka, Masao. / Different Hormonal Expression Patterns between Primary Pancreatic Neuroendocrine Tumors and Metastatic Sites. In: Pancreas. 2016 ; Vol. 45, No. 7. pp. 947-952.
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AU - Cases, Ana Ines

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AU - Oda, Yoshinao

AU - Nakamura, Masafumi

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N2 - Objectives Pancreatic neuroendocrine tumors (PNETs) are known to have heterogeneity in terms of their ability to produce multiple hormones. The aim of this study was to evaluate the heterogeneity of PNETs from the viewpoint of hormonal expression. Methods The expressions of 4 representative hormones, gastrin, insulin, glucagon, and somatostatin, in both primary and metastatic lesions, were analyzed by immunohistochemical staining in 20 patients with metastatic PNETs (6 gastrinomas, 1 insulinoma, 1 glucagonoma, and 12 nonfunctioning PNETs [NF-PNETs]). Metastatic sites included lymph nodes in all 20 patients and liver metastasis in 7 patients (2 gastrinomas and 5 NF-PNETs). Results There were 6 PNETs with multiple hormone secretion (30%), and positive expression of 1 or more hormones was found in 9 of 12 patients whose primary tumors were diagnosed as NF-PNETs. The positive concordance rate of the hormonal expression pattern between primary tumors and metastatic lymph nodes and between primary tumors and hepatic metastasis were 50% and 11%, respectively. Three patients had metastatic lesions with positive hormonal expression, whereas their primary tumors were negative. Conclusions Hormonal expressions are often different between the primary tumors and metastatic sites of PNETs.

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