Different Risk Factors Related to Adenovirus- or BK Virus-Associated Hemorrhagic Cystitis following Allogeneic Stem Cell Transplantation

Yasuo Mori, Toshihiro Miyamoto, Koji Kato, Kenjiro Kamezaki, Takuro Kuriyama, Seido Oku, Katsuto Takenaka, Hiromi Iwasaki, Naoki Harada, Motoaki Shiratsuchi, Yasunobu Abe, Koji Nagafuji, Takanori Teshima, Koichi Akashi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Virus-associated hemorrhagic cystitis (HC) is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (HSCT). Although numerous studies have attempted to identify factors that predispose patients to viral HC, its causes remain controversial. We analyzed retrospectively the results of 266 allogeneic HSCTs to identify factors associated with HC. Of this group, 42 patients (15.8%) were diagnosed with viral HC, because of either adenovirus (ADV; n = 26; 9.8%) or BK virus (BKV; n = 16; 6.0%). ADV-HC was frequently associated with T cell purging, and was less common in patients with acute graft-versus-host-disease (GVHD). Conversely, BKV-HC was more frequently observed in patients with excessive immune reactions such as GVHD, preengraftment immune reaction, and hemophagocytic syndrome. These observations indicate that ADV- and BKV-HC may differ significantly in their risk factors and pathogenesis. Profound immune deficiency is more likely to be associated with ADV-HC, whereas immune hyperactivity might play a key role in BKV-HC.

Original languageEnglish
Pages (from-to)458-465
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume18
Issue number3
DOIs
Publication statusPublished - Mar 1 2012

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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