Differential antitumor immunity caused by cytokine immunogene therapy

T. Ogawa, Eishi Nagai, K. Kusumoto

Research output: Contribution to journalReview articlepeer-review

Abstract

We investigated the effects of immunogene therapy using cytokines (GM- CSF, MCP-1, IFN-γ) that activate macrophages. IFN-γ completely inhibited the growth of mouse malignant melanoma, colon cancer, and renal cancer cells in a tumorigenicity study. On the other hand, MCP-1 showed a tendency to enhance tumor growth. GM-CSF significantly inhibited tumor growth in a tumor vaccination study. Our results demonstrated the different effects of cytokines on tumor growth. It is important to understand the mechanism by which a cytokine exerts its antitumor effects.

Original languageEnglish
Pages (from-to)794-796
Number of pages3
JournalBiotherapy
Volume13
Issue number7
Publication statusPublished - Sep 3 1999

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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