Differential effect of walnut oil and safflower oil on the serum cholesterol level and lesion area in the aortic root of apolipoprotein E-deficient mice

Masako Iwamoto, Misaki Kono, Daisuke Kawamoto, Hiroko Tomoyori, Masao Sato, Katsumi Imaizumi

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Walnut oil (WO) is a good source of α-linolenic acid. We compared the effects of WO and high-linoleic safflower oil (HLSO) on the serum lipid level and atherosclerosis development in male and female apolipoprotein (apo) E-deficient mice. The WO diet resulted in a higher level of serum cholesterol than with HLSO. Female mice fed on the WO diet had a greater lesion area in the aortic root than did those on the HLSO diet. There was no diet-dependent difference in the level of cholesterol and its oxidation products in the abdominal and thoracic aorta. These results suggest that the unpleasant effects of the WO diet on apo E-deficient mice may be attributable to α-linolenic acid.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number1
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Differential effect of walnut oil and safflower oil on the serum cholesterol level and lesion area in the aortic root of apolipoprotein E-deficient mice'. Together they form a unique fingerprint.

Cite this