TY - JOUR
T1 - Differential effects of type 2 diabetes on brain glycometabolism in rats
T2 - focus on glycogen and monocarboxylate transporter 2
AU - Shima, Takeru
AU - Jesmin, Subrina
AU - Matsui, Takashi
AU - Soya, Mariko
AU - Soya, Hideaki
N1 - Funding Information:
Acknowledgements The authors are grateful to Randeep Rakwal, Yu-Fan Liu, Naoki Omori, Katsuhito Saito (University of Tsukuba, Japan) for technical support and discussion, and to Melissa Noguchi (ELCS English Language Consultation, Japan) for help with the manuscript. This study was funded by the ‘‘Global Initiative for Sports Neuroscience (GISN): For Development of Exercise Prescription Enhancing Cognitive Functions,’’ by special funds for Education and Research of the Ministry of Education, Culture, Sports, Science and Technology (MEXT) granted to the ‘‘Body and Mind Integrated Sports Sciences (BAMIS) Project’’ and to the ‘‘Human High Performance (HHP) Research Project,’’ and by the Japan Society for the Promotion of Science (Grants-in-aid for Scientific Research A, No. 15H01828; Challenging Exploratory Research, No. 23650384).
Publisher Copyright:
© 2016, The Physiological Society of Japan and Springer Japan.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Astrocyte-neuron lactate shuttle (ANLS) is a pathway that supplies glycogen-derived lactate to active neurons via monocarboxylate transporter 2 (MCT2), and is important for maintaining brain functions. Our study revealed alterations of ANLS with hippocampal hyper-glycogen levels and downregulated MCT2 protein levels underlying hippocampal dysfunctions as a complication in type 2 diabetic (T2DM) animals. Since T2DM rats exhibit brain dysfunctions involving several brain regions, we examined whether there might also be T2DM effects on ANLS’s disturbances in other brain loci. OLETF rats exhibited significantly higher glycogen levels in the hippocampus, hypothalamus, and cerebral cortex than did LETO rats. MCT2 protein levels in OLETF rats decreased significantly in the hippocampus and hypothalamus compared to their controls, but a significant correlation with glycogen levels was only observed in the hippocampus. This suggests that the hippocampus may be more vulnerable to T2DM compared to other brain regions in the context of ANLS disruption.
AB - Astrocyte-neuron lactate shuttle (ANLS) is a pathway that supplies glycogen-derived lactate to active neurons via monocarboxylate transporter 2 (MCT2), and is important for maintaining brain functions. Our study revealed alterations of ANLS with hippocampal hyper-glycogen levels and downregulated MCT2 protein levels underlying hippocampal dysfunctions as a complication in type 2 diabetic (T2DM) animals. Since T2DM rats exhibit brain dysfunctions involving several brain regions, we examined whether there might also be T2DM effects on ANLS’s disturbances in other brain loci. OLETF rats exhibited significantly higher glycogen levels in the hippocampus, hypothalamus, and cerebral cortex than did LETO rats. MCT2 protein levels in OLETF rats decreased significantly in the hippocampus and hypothalamus compared to their controls, but a significant correlation with glycogen levels was only observed in the hippocampus. This suggests that the hippocampus may be more vulnerable to T2DM compared to other brain regions in the context of ANLS disruption.
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U2 - 10.1007/s12576-016-0508-6
DO - 10.1007/s12576-016-0508-6
M3 - Article
C2 - 27987117
AN - SCOPUS:85006512010
VL - 68
SP - 69
EP - 75
JO - Journal of Physiological Sciences
JF - Journal of Physiological Sciences
SN - 1880-6546
IS - 1
ER -
