Differential expression and allelotyping of the p73 gene in neuroblastoma.

W. Liu, M. Mai, Akira Yokomizo, C. Qian, D. J. Tindall, D. I. Smith, S. N. Thibodeau

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

p73 has recently been identified as a candidate imprinted tumor suppressor gene in neuroblastoma. To determine the possible involvement of this gene in the pathogenesis of neuroblastoma, we analyzed allelic expression, screened for mutations and determined MYCN copy numbers in 31 primary neuroblastoma tumor samples. Interestingly, the gene was biallelically expressed in 50% (4/8) of informative neuroblastomas, which suggests that activation of the normally silenced allele of this gene plays an important role in the tumorigenesis of neuroblastoma. However, no tumor-specific mutations were identified although 15 polymorphisms were detected in this gene. We also detected a very strong association between a C91T polymorphism and MYCN copy number in this tumor. The T allele was detected in 8/17 (47%) neuroblastomas without MYCN amplifications but not detected in cases with MYCN amplifications (0/14). The biological significance of this association, however, is unknown. Overall the data suggest that p73 may play an important role in the pathogenesis of neuroblastoma but that the true tumor suppressor gene localized to this area still remains to be identified.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalInternational journal of oncology
Volume16
Issue number1
Publication statusPublished - Jan 1 2000

Fingerprint

Neuroblastoma
Genes
Tumor Suppressor Genes
Alleles
DNA Copy Number Variations
Neoplasms
Mutation
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Liu, W., Mai, M., Yokomizo, A., Qian, C., Tindall, D. J., Smith, D. I., & Thibodeau, S. N. (2000). Differential expression and allelotyping of the p73 gene in neuroblastoma. International journal of oncology, 16(1), 181-185.

Differential expression and allelotyping of the p73 gene in neuroblastoma. / Liu, W.; Mai, M.; Yokomizo, Akira; Qian, C.; Tindall, D. J.; Smith, D. I.; Thibodeau, S. N.

In: International journal of oncology, Vol. 16, No. 1, 01.01.2000, p. 181-185.

Research output: Contribution to journalArticle

Liu, W, Mai, M, Yokomizo, A, Qian, C, Tindall, DJ, Smith, DI & Thibodeau, SN 2000, 'Differential expression and allelotyping of the p73 gene in neuroblastoma.', International journal of oncology, vol. 16, no. 1, pp. 181-185.
Liu W, Mai M, Yokomizo A, Qian C, Tindall DJ, Smith DI et al. Differential expression and allelotyping of the p73 gene in neuroblastoma. International journal of oncology. 2000 Jan 1;16(1):181-185.
Liu, W. ; Mai, M. ; Yokomizo, Akira ; Qian, C. ; Tindall, D. J. ; Smith, D. I. ; Thibodeau, S. N. / Differential expression and allelotyping of the p73 gene in neuroblastoma. In: International journal of oncology. 2000 ; Vol. 16, No. 1. pp. 181-185.
@article{ba764e98cfc641949c726ddd81c9d21f,
title = "Differential expression and allelotyping of the p73 gene in neuroblastoma.",
abstract = "p73 has recently been identified as a candidate imprinted tumor suppressor gene in neuroblastoma. To determine the possible involvement of this gene in the pathogenesis of neuroblastoma, we analyzed allelic expression, screened for mutations and determined MYCN copy numbers in 31 primary neuroblastoma tumor samples. Interestingly, the gene was biallelically expressed in 50{\%} (4/8) of informative neuroblastomas, which suggests that activation of the normally silenced allele of this gene plays an important role in the tumorigenesis of neuroblastoma. However, no tumor-specific mutations were identified although 15 polymorphisms were detected in this gene. We also detected a very strong association between a C91T polymorphism and MYCN copy number in this tumor. The T allele was detected in 8/17 (47{\%}) neuroblastomas without MYCN amplifications but not detected in cases with MYCN amplifications (0/14). The biological significance of this association, however, is unknown. Overall the data suggest that p73 may play an important role in the pathogenesis of neuroblastoma but that the true tumor suppressor gene localized to this area still remains to be identified.",
author = "W. Liu and M. Mai and Akira Yokomizo and C. Qian and Tindall, {D. J.} and Smith, {D. I.} and Thibodeau, {S. N.}",
year = "2000",
month = "1",
day = "1",
language = "English",
volume = "16",
pages = "181--185",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "1",

}

TY - JOUR

T1 - Differential expression and allelotyping of the p73 gene in neuroblastoma.

AU - Liu, W.

AU - Mai, M.

AU - Yokomizo, Akira

AU - Qian, C.

AU - Tindall, D. J.

AU - Smith, D. I.

AU - Thibodeau, S. N.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - p73 has recently been identified as a candidate imprinted tumor suppressor gene in neuroblastoma. To determine the possible involvement of this gene in the pathogenesis of neuroblastoma, we analyzed allelic expression, screened for mutations and determined MYCN copy numbers in 31 primary neuroblastoma tumor samples. Interestingly, the gene was biallelically expressed in 50% (4/8) of informative neuroblastomas, which suggests that activation of the normally silenced allele of this gene plays an important role in the tumorigenesis of neuroblastoma. However, no tumor-specific mutations were identified although 15 polymorphisms were detected in this gene. We also detected a very strong association between a C91T polymorphism and MYCN copy number in this tumor. The T allele was detected in 8/17 (47%) neuroblastomas without MYCN amplifications but not detected in cases with MYCN amplifications (0/14). The biological significance of this association, however, is unknown. Overall the data suggest that p73 may play an important role in the pathogenesis of neuroblastoma but that the true tumor suppressor gene localized to this area still remains to be identified.

AB - p73 has recently been identified as a candidate imprinted tumor suppressor gene in neuroblastoma. To determine the possible involvement of this gene in the pathogenesis of neuroblastoma, we analyzed allelic expression, screened for mutations and determined MYCN copy numbers in 31 primary neuroblastoma tumor samples. Interestingly, the gene was biallelically expressed in 50% (4/8) of informative neuroblastomas, which suggests that activation of the normally silenced allele of this gene plays an important role in the tumorigenesis of neuroblastoma. However, no tumor-specific mutations were identified although 15 polymorphisms were detected in this gene. We also detected a very strong association between a C91T polymorphism and MYCN copy number in this tumor. The T allele was detected in 8/17 (47%) neuroblastomas without MYCN amplifications but not detected in cases with MYCN amplifications (0/14). The biological significance of this association, however, is unknown. Overall the data suggest that p73 may play an important role in the pathogenesis of neuroblastoma but that the true tumor suppressor gene localized to this area still remains to be identified.

UR - http://www.scopus.com/inward/record.url?scp=0033629306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033629306&partnerID=8YFLogxK

M3 - Article

C2 - 10601564

AN - SCOPUS:0033629306

VL - 16

SP - 181

EP - 185

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 1

ER -