Differential expression of insulin-like growth factor 1 in human primary liver cancer.

Yasuharu Ikeda, Kiyoshi Kajiyama, Yo Ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Tetsuo Ikeda, Masaru Morita, Eiji Oki, Hiroshi Saeki, Taketoshi Suehiro, Kohshi Mimori, Keishi Sugimachi, Ken Shirabe, Yoshihiko Maehara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Insulin-like Growth Factor 1 (IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)334-338
Number of pages5
JournalUnknown Journal
Volume104
Issue number10
Publication statusPublished - Oct 2013

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Somatomedins
Liver Neoplasms
cancer
lesion
Hepatocellular Carcinoma
Liver
Hepatectomy
Portal Vein
antigen
infiltration
Antigens

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ikeda, Y., Kajiyama, K., Yamashita, Y. I., Ikegami, T., Uchiyama, H., Soejima, Y., ... Maehara, Y. (2013). Differential expression of insulin-like growth factor 1 in human primary liver cancer. Unknown Journal, 104(10), 334-338.

Differential expression of insulin-like growth factor 1 in human primary liver cancer. / Ikeda, Yasuharu; Kajiyama, Kiyoshi; Yamashita, Yo Ichi; Ikegami, Toru; Uchiyama, Hideaki; Soejima, Yuji; Kawanaka, Hirofumi; Ikeda, Tetsuo; Morita, Masaru; Oki, Eiji; Saeki, Hiroshi; Suehiro, Taketoshi; Mimori, Kohshi; Sugimachi, Keishi; Shirabe, Ken; Maehara, Yoshihiko.

In: Unknown Journal, Vol. 104, No. 10, 10.2013, p. 334-338.

Research output: Contribution to journalArticle

Ikeda, Y, Kajiyama, K, Yamashita, YI, Ikegami, T, Uchiyama, H, Soejima, Y, Kawanaka, H, Ikeda, T, Morita, M, Oki, E, Saeki, H, Suehiro, T, Mimori, K, Sugimachi, K, Shirabe, K & Maehara, Y 2013, 'Differential expression of insulin-like growth factor 1 in human primary liver cancer.', Unknown Journal, vol. 104, no. 10, pp. 334-338.
Ikeda Y, Kajiyama K, Yamashita YI, Ikegami T, Uchiyama H, Soejima Y et al. Differential expression of insulin-like growth factor 1 in human primary liver cancer. Unknown Journal. 2013 Oct;104(10):334-338.
Ikeda, Yasuharu ; Kajiyama, Kiyoshi ; Yamashita, Yo Ichi ; Ikegami, Toru ; Uchiyama, Hideaki ; Soejima, Yuji ; Kawanaka, Hirofumi ; Ikeda, Tetsuo ; Morita, Masaru ; Oki, Eiji ; Saeki, Hiroshi ; Suehiro, Taketoshi ; Mimori, Kohshi ; Sugimachi, Keishi ; Shirabe, Ken ; Maehara, Yoshihiko. / Differential expression of insulin-like growth factor 1 in human primary liver cancer. In: Unknown Journal. 2013 ; Vol. 104, No. 10. pp. 334-338.
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