Differential response of type 2 deiodinase gene expression to photoperiod between photoperiodic Fischer 344 and nonphotoperiodic Wistar rats

Shinobu Yasuo, Miwa Watanabe, Masayuki Iigo, Takahiro J. Nakamura, Tsuyoshi Watanabe, Tsuyoshi Takagi, Hiroko Ono, Shizufumi Ebihara, Takashi Yoshimura

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The molecular basis of seasonal or nonseasonal breeding remains unknown. Although laboratory rats are generally regarded as photoperiod-insensitive species, the testicular weight of the Fischer 344 (F344) strain responds to photoperiod. Recently, it was clarified that photoperiodic regulation of type 2 iodothyronine deiodinase (Dio2) in the mediobasal hypothalamus (MBH) is critical in photoperiodic gonadal regulation. Strain-dependent differences in photoperiod sensitivity may now provide the opportunity to address the regulatory mechanism of seasonality by studying Dio2 expression. Therefore, in the present study, we examined the effect of photoperiod on Dio2 expression in photoperiod-sensitive F344 and photoperiod-insensitive Wistar rats. A statistically significant difference was observed between short and long days in terms of testicular weight and Dio2 expression in the F344 strain, while no difference was observed in the Wistar strain. These results suggest that differential responses of the Dio2 gene to photoperiod may determine the strain-dependent differences in photoperiod sensitivity in laboratory rats.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume292
Issue number3
DOIs
Publication statusPublished - Mar 1 2007
Externally publishedYes

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Iodide Peroxidase
Photoperiod
Wistar Rats
Gene Expression
Weights and Measures
Hypothalamus
Breeding

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Differential response of type 2 deiodinase gene expression to photoperiod between photoperiodic Fischer 344 and nonphotoperiodic Wistar rats. / Yasuo, Shinobu; Watanabe, Miwa; Iigo, Masayuki; Nakamura, Takahiro J.; Watanabe, Tsuyoshi; Takagi, Tsuyoshi; Ono, Hiroko; Ebihara, Shizufumi; Yoshimura, Takashi.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 292, No. 3, 01.03.2007.

Research output: Contribution to journalArticle

Yasuo, Shinobu ; Watanabe, Miwa ; Iigo, Masayuki ; Nakamura, Takahiro J. ; Watanabe, Tsuyoshi ; Takagi, Tsuyoshi ; Ono, Hiroko ; Ebihara, Shizufumi ; Yoshimura, Takashi. / Differential response of type 2 deiodinase gene expression to photoperiod between photoperiodic Fischer 344 and nonphotoperiodic Wistar rats. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2007 ; Vol. 292, No. 3.
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