TY - JOUR
T1 - Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity
AU - Matsuzaki, Junko
AU - Kagitani-Shimono, Kuriko
AU - Goto, Tetsu
AU - Sanefuji, Wakako
AU - Yamamoto, Tomoka
AU - Sakai, Saeko
AU - Uchida, Hiroyuki
AU - Hirata, Masayuki
AU - Mohri, Ikuko
AU - Yorifuji, Shiro
AU - Taniike, Masako
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/1/25
Y1 - 2012/1/25
N2 - The aim of this study was to investigate the differential responses of the primary auditory cortex to auditory stimuli in autistic spectrum disorder with or without auditory hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine with and nine without auditory hypersensitivity) with autistic spectrum disorder and 12 age-matched controls. Autistic disorder with hypersensitivity showed significantly more delayed M50/M100 peak latencies than autistic disorder without hypersensitivity or the control. M50 dipole moments in the hypersensitivity group were statistically larger than those in the other two groups. M50/M100 peak latencies were correlated with the severity of auditory hypersensitivity; furthermore, severe hypersensitivity induced more behavioral problems. This study indicates auditory hypersensitivity in autistic spectrum disorder as a characteristic response of the primary auditory cortex, possibly resulting from neurological immaturity or functional abnormalities in it.
AB - The aim of this study was to investigate the differential responses of the primary auditory cortex to auditory stimuli in autistic spectrum disorder with or without auditory hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine with and nine without auditory hypersensitivity) with autistic spectrum disorder and 12 age-matched controls. Autistic disorder with hypersensitivity showed significantly more delayed M50/M100 peak latencies than autistic disorder without hypersensitivity or the control. M50 dipole moments in the hypersensitivity group were statistically larger than those in the other two groups. M50/M100 peak latencies were correlated with the severity of auditory hypersensitivity; furthermore, severe hypersensitivity induced more behavioral problems. This study indicates auditory hypersensitivity in autistic spectrum disorder as a characteristic response of the primary auditory cortex, possibly resulting from neurological immaturity or functional abnormalities in it.
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U2 - 10.1097/WNR.0b013e32834ebf44
DO - 10.1097/WNR.0b013e32834ebf44
M3 - Article
C2 - 22146579
AN - SCOPUS:84855349345
VL - 23
SP - 113
EP - 118
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 2
ER -