Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity

Junko Matsuzaki; Kuriko Kagitani-Shimono; Tetsu Goto; Wakako Sanefuji; Tomoka Yamamoto; Saeko Sakai; Hiroyuki Uchida; Masayuki Hirata; Ikuko Mohri; Shiro Yorifuji; Masako Taniike

doi:10.1097/WNR.0b013e32834ebf44

Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity

Junko Matsuzaki, Kuriko Kagitani-Shimono, Tetsu Goto, Wakako Sanefuji, Tomoka Yamamoto, Saeko Sakai, Hiroyuki Uchida, Masayuki Hirata, Ikuko Mohri, Shiro Yorifuji, Masako Taniike

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The aim of this study was to investigate the differential responses of the primary auditory cortex to auditory stimuli in autistic spectrum disorder with or without auditory hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine with and nine without auditory hypersensitivity) with autistic spectrum disorder and 12 age-matched controls. Autistic disorder with hypersensitivity showed significantly more delayed M50/M100 peak latencies than autistic disorder without hypersensitivity or the control. M50 dipole moments in the hypersensitivity group were statistically larger than those in the other two groups. M50/M100 peak latencies were correlated with the severity of auditory hypersensitivity; furthermore, severe hypersensitivity induced more behavioral problems. This study indicates auditory hypersensitivity in autistic spectrum disorder as a characteristic response of the primary auditory cortex, possibly resulting from neurological immaturity or functional abnormalities in it.

Original language	English
Pages (from-to)	113-118
Number of pages	6
Journal	NeuroReport
Volume	23
Issue number	2
DOIs	https://doi.org/10.1097/WNR.0b013e32834ebf44
Publication status	Published - Jan 25 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1097/WNR.0b013e32834ebf44

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Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity. / Matsuzaki, Junko; Kagitani-Shimono, Kuriko; Goto, Tetsu; Sanefuji, Wakako; Yamamoto, Tomoka; Sakai, Saeko; Uchida, Hiroyuki; Hirata, Masayuki; Mohri, Ikuko; Yorifuji, Shiro; Taniike, Masako.

In: NeuroReport, Vol. 23, No. 2, 25.01.2012, p. 113-118.

Research output: Contribution to journal › Article › peer-review

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AU - Sakai, Saeko

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