Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity

Junko Matsuzaki, Kuriko Kagitani-Shimono, Tetsu Goto, Wakako Sanefuji, Tomoka Yamamoto, Saeko Sakai, Hiroyuki Uchida, Masayuki Hirata, Ikuko Mohri, Shiro Yorifuji, Masako Taniike

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Abstract

The aim of this study was to investigate the differential responses of the primary auditory cortex to auditory stimuli in autistic spectrum disorder with or without auditory hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine with and nine without auditory hypersensitivity) with autistic spectrum disorder and 12 age-matched controls. Autistic disorder with hypersensitivity showed significantly more delayed M50/M100 peak latencies than autistic disorder without hypersensitivity or the control. M50 dipole moments in the hypersensitivity group were statistically larger than those in the other two groups. M50/M100 peak latencies were correlated with the severity of auditory hypersensitivity; furthermore, severe hypersensitivity induced more behavioral problems. This study indicates auditory hypersensitivity in autistic spectrum disorder as a characteristic response of the primary auditory cortex, possibly resulting from neurological immaturity or functional abnormalities in it.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalNeuroReport
Volume23
Issue number2
DOIs
Publication statusPublished - Jan 25 2012
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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