Differentially expressed MHC class II-associated invariant chain in rat stomach pyloric mucosa with N-methyl-N'-nitro-N-nitrosoguanidine exposure

Chie Furihata, Masashi Oka, Masami Yamamoto, Takashi Ito, Masao Ichinose, Kazumasa Miki, Masae Tatematsu, Yoshiyuki Sakaki, Konrad Reske

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14 Citations (Scopus)

Abstract

Administration of N-methyl-N'-nitro-N-nitrosoguanidine, a glandular stomach carcinogen, at the concentration of 100 μg/ml in drinking water for 8 days induced the appearance of a MHC class II-associated invariant chain in the target organ of stomach pyloric mucosa of male Lewis rats. The up- regulation of the MHC class II-associated invariant chain was revealed by fluorescent differential display analysis, reverse transcription-PCR, Northern blot, and histochemical staining. The appearance of MHC class II and MHC class I was also demonstrated by reverse transcription-PCR and Northern blot. The results suggest the involvement of MHC-controlled immune reactions in chemically-induced stomach carcinogenesis.

Original languageEnglish
Pages (from-to)1416-1418
Number of pages3
JournalCancer Research
Volume57
Issue number8
Publication statusPublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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