Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product

T. Maeda, M. K. Owada, H. Sugiyama, S. Miyake, Y. Tani, H. Ogawa, Y. Oka, T. Komori, T. Soma, S. Kishimoto, J. Seki, N. Sakato, A. Hakura

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Abstract

The expression of v-abl oncogene during the in vitro differentiation of an Abelson-virus-transformed immature B precursor cell line from immunoglobulin-null to intracytoplasmic μ-positive cells and further to intracytoplasmic γ2b-positive cells was examined. The results showed no significant alteration in the amounts and tyrosine kinase activity of v-abl oncogene product during differentiation, indicating that B cell differentiation processes are independent of v-abl functions.

Original languageEnglish
Pages (from-to)263-269
Number of pages7
JournalCell Differentiation
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 1987
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Developmental Biology

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