Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product

Toyoki Maeda, M. K. Owada, H. Sugiyama, S. Miyake, Y. Tani, H. Ogawa, Y. Oka, T. Komori, T. Soma, S. Kishimoto, J. Seki, N. Sakato, A. Hakura

Research output: Contribution to journalArticle

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Abstract

The expression of v-abl oncogene during the in vitro differentiation of an Abelson-virus-transformed immature B precursor cell line from immunoglobulin-null to intracytoplasmic μ-positive cells and further to intracytoplasmic γ2b-positive cells was examined. The results showed no significant alteration in the amounts and tyrosine kinase activity of v-abl oncogene product during differentiation, indicating that B cell differentiation processes are independent of v-abl functions.

Original languageEnglish
Pages (from-to)263-269
Number of pages7
JournalCell Differentiation
Volume20
Issue number4
DOIs
Publication statusPublished - Jan 1 1987
Externally publishedYes

Fingerprint

Oncogene Proteins v-abl
B-Lymphoid Precursor Cells
Protein-Tyrosine Kinases
abl Genes
Viruses
Cell Line
Immunoglobulins
Cell Differentiation
B-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Cite this

Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product. / Maeda, Toyoki; Owada, M. K.; Sugiyama, H.; Miyake, S.; Tani, Y.; Ogawa, H.; Oka, Y.; Komori, T.; Soma, T.; Kishimoto, S.; Seki, J.; Sakato, N.; Hakura, A.

In: Cell Differentiation, Vol. 20, No. 4, 01.01.1987, p. 263-269.

Research output: Contribution to journalArticle

Maeda, T, Owada, MK, Sugiyama, H, Miyake, S, Tani, Y, Ogawa, H, Oka, Y, Komori, T, Soma, T, Kishimoto, S, Seki, J, Sakato, N & Hakura, A 1987, 'Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product', Cell Differentiation, vol. 20, no. 4, pp. 263-269. https://doi.org/10.1016/0045-6039(87)90471-4
Maeda, Toyoki ; Owada, M. K. ; Sugiyama, H. ; Miyake, S. ; Tani, Y. ; Ogawa, H. ; Oka, Y. ; Komori, T. ; Soma, T. ; Kishimoto, S. ; Seki, J. ; Sakato, N. ; Hakura, A. / Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product. In: Cell Differentiation. 1987 ; Vol. 20, No. 4. pp. 263-269.
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