Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product

T. Maeda, M. K. Owada, H. Sugiyama, S. Miyake, Y. Tani, H. Ogawa, Y. Oka, T. Komori, T. Soma, S. Kishimoto, J. Seki, N. Sakato, A. Hakura

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The expression of v-abl oncogene during the in vitro differentiation of an Abelson-virus-transformed immature B precursor cell line from immunoglobulin-null to intracytoplasmic μ-positive cells and further to intracytoplasmic γ2b-positive cells was examined. The results showed no significant alteration in the amounts and tyrosine kinase activity of v-abl oncogene product during differentiation, indicating that B cell differentiation processes are independent of v-abl functions.

Original languageEnglish
Pages (from-to)263-269
Number of pages7
JournalCell Differentiation
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Developmental Biology

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