Differentiation of hypointense nodules on gadoxetic acid-enhanced hepatobiliary-phase MRI using T2 enhanced spin-echo imaging with the time-reversed gradient echo sequence

An initial experience

Masami Yoneyama, Yukihisa Takayama, Akihiro Nishie, Masanobu Nakamura, Yasutomo Katsumata, Atsushi Takemura, Makoto Obara, Tomoyuki Okuaki, Hiroshi Honda, Marc Van Cauteren

Research output: Contribution to journalArticle

Abstract

Purpose To optimize the flip angle (FA) of the T2 enhanced spin-echo imaging using the time reversed gradient echo (T2FFE) and evaluate its utility for differentiating hypointensity nodules in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced (Gd-EOB) MRI. Materials and methods First, FA optimization of the T2FFE in the HBP was investigated by comparing signal-to-noise ratio (SNR) among different FAs using phantoms. The liver-to-muscle contrast ratios (CRLiver-Muscle) and image quality among three FAs (20°, 50° and 80°) were compared using images of 10 patients. Next, the utility of the T2FFE with an optimized FA for differentiating hypointensity nodules in the HBP was assessed by comparing the lesion-to-liver contrast ratio (CRLesion-Liver) among cysts, hemangiomas, hepatocellular carcinomas, and metastatic tumors in 32 patients. Results SNR increased as FA increased, but leveled off at FAs of 50° and greater. The FA of 50° showed significantly better image quality scores than that of 80° (p < 0.05). After employing an FA of 50°, the CRLesion-Liver value indicated that the T2FFE depicted benign lesions as hyperintense and most malignant lesions as hypointense in relation with the liver parenchyma (p < 0.05). Conclusion The T2FFE in the HBP of Gd-EOB-MRI is useful for differentiating benign and malignant liver lesions.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalEuropean Journal of Radiology
Volume95
DOIs
Publication statusPublished - Oct 1 2017

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Magnetic Resonance Imaging
Liver
Signal-To-Noise Ratio
Muscles
Hemangioma
Cysts
Hepatocellular Carcinoma
gadolinium ethoxybenzyl DTPA
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Differentiation of hypointense nodules on gadoxetic acid-enhanced hepatobiliary-phase MRI using T2 enhanced spin-echo imaging with the time-reversed gradient echo sequence : An initial experience. / Yoneyama, Masami; Takayama, Yukihisa; Nishie, Akihiro; Nakamura, Masanobu; Katsumata, Yasutomo; Takemura, Atsushi; Obara, Makoto; Okuaki, Tomoyuki; Honda, Hiroshi; Van Cauteren, Marc.

In: European Journal of Radiology, Vol. 95, 01.10.2017, p. 325-331.

Research output: Contribution to journalArticle

Yoneyama, Masami ; Takayama, Yukihisa ; Nishie, Akihiro ; Nakamura, Masanobu ; Katsumata, Yasutomo ; Takemura, Atsushi ; Obara, Makoto ; Okuaki, Tomoyuki ; Honda, Hiroshi ; Van Cauteren, Marc. / Differentiation of hypointense nodules on gadoxetic acid-enhanced hepatobiliary-phase MRI using T2 enhanced spin-echo imaging with the time-reversed gradient echo sequence : An initial experience. In: European Journal of Radiology. 2017 ; Vol. 95. pp. 325-331.
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abstract = "Purpose To optimize the flip angle (FA) of the T2 enhanced spin-echo imaging using the time reversed gradient echo (T2FFE) and evaluate its utility for differentiating hypointensity nodules in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced (Gd-EOB) MRI. Materials and methods First, FA optimization of the T2FFE in the HBP was investigated by comparing signal-to-noise ratio (SNR) among different FAs using phantoms. The liver-to-muscle contrast ratios (CRLiver-Muscle) and image quality among three FAs (20°, 50° and 80°) were compared using images of 10 patients. Next, the utility of the T2FFE with an optimized FA for differentiating hypointensity nodules in the HBP was assessed by comparing the lesion-to-liver contrast ratio (CRLesion-Liver) among cysts, hemangiomas, hepatocellular carcinomas, and metastatic tumors in 32 patients. Results SNR increased as FA increased, but leveled off at FAs of 50° and greater. The FA of 50° showed significantly better image quality scores than that of 80° (p < 0.05). After employing an FA of 50°, the CRLesion-Liver value indicated that the T2FFE depicted benign lesions as hyperintense and most malignant lesions as hypointense in relation with the liver parenchyma (p < 0.05). Conclusion The T2FFE in the HBP of Gd-EOB-MRI is useful for differentiating benign and malignant liver lesions.",
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T2 - An initial experience

AU - Yoneyama, Masami

AU - Takayama, Yukihisa

AU - Nishie, Akihiro

AU - Nakamura, Masanobu

AU - Katsumata, Yasutomo

AU - Takemura, Atsushi

AU - Obara, Makoto

AU - Okuaki, Tomoyuki

AU - Honda, Hiroshi

AU - Van Cauteren, Marc

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AB - Purpose To optimize the flip angle (FA) of the T2 enhanced spin-echo imaging using the time reversed gradient echo (T2FFE) and evaluate its utility for differentiating hypointensity nodules in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced (Gd-EOB) MRI. Materials and methods First, FA optimization of the T2FFE in the HBP was investigated by comparing signal-to-noise ratio (SNR) among different FAs using phantoms. The liver-to-muscle contrast ratios (CRLiver-Muscle) and image quality among three FAs (20°, 50° and 80°) were compared using images of 10 patients. Next, the utility of the T2FFE with an optimized FA for differentiating hypointensity nodules in the HBP was assessed by comparing the lesion-to-liver contrast ratio (CRLesion-Liver) among cysts, hemangiomas, hepatocellular carcinomas, and metastatic tumors in 32 patients. Results SNR increased as FA increased, but leveled off at FAs of 50° and greater. The FA of 50° showed significantly better image quality scores than that of 80° (p < 0.05). After employing an FA of 50°, the CRLesion-Liver value indicated that the T2FFE depicted benign lesions as hyperintense and most malignant lesions as hypointense in relation with the liver parenchyma (p < 0.05). Conclusion The T2FFE in the HBP of Gd-EOB-MRI is useful for differentiating benign and malignant liver lesions.

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