Differentiation of periodontal ligament stem/progenitor cells: Roles of TGF-β1

Hidefumi Maeda; Shinsuke Fujii; Satoshi Monnouchi; Naohisa Wada; Akifumi Akamine

doi:10.1007/978-94-007-2828-8_5

Differentiation of periodontal ligament stem/progenitor cells: Roles of TGF-β1

Hidefumi Maeda, Shinsuke Fujii, Satoshi Monnouchi, Naohisa Wada, Akifumi Akamine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Tooth loss provokes loss of occlusal function, resulting in a decreased quality of life. Tooth loss is related primarily to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases, or irreversible trauma. Periodontal ligament (PDL) is a central tissue in periodontium and contains stem/progenitor cells that are believed to have the potential to regenerate periodontium, including PDL tissue. For this reason, we and other groups have focused on such undifferentiated cells to elucidate their applicable potentials for PDL regenerative medicine based on cell-based tissue engineering. However, how their differentiation is controlled remains unclear. We recently suggested that transforming growth factor-beta 1 is a candidate factor for regulation of fibroblastic differentiation of stem/progenitor cells in PDL tissue.

Original language	English
Title of host publication	Stem Cells and Cancer Stem Cells, Volume 4
Subtitle of host publication	Therapeutic Applications in Disease and Injury
Publisher	Springer Netherlands
Pages	51-58
Number of pages	8
ISBN (Electronic)	9789400728288
ISBN (Print)	9789400728271
DOIs	https://doi.org/10.1007/978-94-007-2828-8_5
Publication status	Published - Jan 1 2012

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1007/978-94-007-2828-8_5

Cite this

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abstract = "Tooth loss provokes loss of occlusal function, resulting in a decreased quality of life. Tooth loss is related primarily to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases, or irreversible trauma. Periodontal ligament (PDL) is a central tissue in periodontium and contains stem/progenitor cells that are believed to have the potential to regenerate periodontium, including PDL tissue. For this reason, we and other groups have focused on such undifferentiated cells to elucidate their applicable potentials for PDL regenerative medicine based on cell-based tissue engineering. However, how their differentiation is controlled remains unclear. We recently suggested that transforming growth factor-beta 1 is a candidate factor for regulation of fibroblastic differentiation of stem/progenitor cells in PDL tissue.",

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AU - Wada, Naohisa

AU - Akamine, Akifumi

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Differentiation of periodontal ligament stem/progenitor cells: Roles of TGF-β1

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