Differentiation of skeletal muscle from pituitary folliculo-stellate cells and endocrine progenitor cells

Chihiro Mogi, Shunsuke Miyai, Yusuke Nishimura, Hitomi Fukuro, Kotaro Yokoyama, Atsushi Takaki, Kinji Inoue

Research output: Contribution to journalArticle

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Abstract

We previously reported the ectopic differentiation of skeletal muscle cells in a pituitary gland transplanted beneath a kidney capsule. Morphological observation suggested that the skeletal muscle cells may have differentiated from folliculo-stellate (FS) cells in the anterior pituitary gland. However, at that time, we did not confirm this directly with an in vitro system. To obtain direct evidence, we used the Tpit/F1 cell line. The Tpit/F1 cell line was recently established from the pituitary gland of a temperature-sensitive T antigen transgenic mouse and has the characters of pituitary FS cells. Using Tpit/F1 cells, we have found that FS cells of the pituitary are able to differentiate into muscle cells in vitro. Additionally, we showed that the cells have some characteristics of pituitary FS cells and also express pituitary endocrine cell-specific transcription factor (pit-1) and prolactin genes, and can differentiate into striated muscle cells. The anterior pituitary gland is known to be of ectodermal origin, so the differentiation of its cells into striated muscle is completely unexpected. This is the first report of direct evidence of ectopic differentiation of skeletal muscle cells from pituitary cells.

Original languageEnglish
Pages (from-to)288-294
Number of pages7
JournalExperimental Cell Research
Volume292
Issue number2
DOIs
Publication statusPublished - Jan 15 2004

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Endocrine Cells
Skeletal Muscle
Stem Cells
Muscle Cells
Anterior Pituitary Gland
Striated Muscle
Pituitary Gland
Transcription Factor Pit-1
Cell Line
Viral Tumor Antigens
Prolactin
Transgenic Mice
Capsules
Cell Differentiation
Observation
Kidney
Temperature
Genes

All Science Journal Classification (ASJC) codes

  • Cell Biology

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Differentiation of skeletal muscle from pituitary folliculo-stellate cells and endocrine progenitor cells. / Mogi, Chihiro; Miyai, Shunsuke; Nishimura, Yusuke; Fukuro, Hitomi; Yokoyama, Kotaro; Takaki, Atsushi; Inoue, Kinji.

In: Experimental Cell Research, Vol. 292, No. 2, 15.01.2004, p. 288-294.

Research output: Contribution to journalArticle

Mogi, Chihiro ; Miyai, Shunsuke ; Nishimura, Yusuke ; Fukuro, Hitomi ; Yokoyama, Kotaro ; Takaki, Atsushi ; Inoue, Kinji. / Differentiation of skeletal muscle from pituitary folliculo-stellate cells and endocrine progenitor cells. In: Experimental Cell Research. 2004 ; Vol. 292, No. 2. pp. 288-294.
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