Differentiation of the DnaA-oriC subcomplex for DNA unwinding in a replication initiation complex

Shogo Ozaki; Yasunori Noguchi; Yasuhisa Hayashi; Erika Miyazaki; Tsutomu Katayama

doi:10.1074/jbc.M112.372052

Differentiation of the DnaA-oriC subcomplex for DNA unwinding in a replication initiation complex

Shogo Ozaki, Yasunori Noguchi, Yasuhisa Hayashi, Erika Miyazaki, Tsutomu Katayama

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Background: Multiple DnaA molecules form highly ordered complexes on the origin DNA to initiate chromosomal replication. Results: Novel structural motifs of DnaA are specifically required for the formation of the DNA unwinding-specific DnaA subcomplex. Conclusion: Distinct inter-DnaA interactions are required for the unwinding-specific subcomplex. Significance: Differentiation of the unwinding-specific subcomplex and a key mechanism underlying it are revealed.

Original language	English
Pages (from-to)	37458-37471
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.372052
Publication status	Published - Oct 26 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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AU - Miyazaki, Erika

AU - Katayama, Tsutomu

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Differentiation of the DnaA-oriC subcomplex for DNA unwinding in a replication initiation complex

Abstract

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