Differentiation of the DnaA-oriC subcomplex for DNA unwinding in a replication initiation complex

Shogo Ozaki, Yasunori Noguchi, Yasuhisa Hayashi, Erika Miyazaki, Tsutomu Katayama

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Background: Multiple DnaA molecules form highly ordered complexes on the origin DNA to initiate chromosomal replication. Results: Novel structural motifs of DnaA are specifically required for the formation of the DNA unwinding-specific DnaA subcomplex. Conclusion: Distinct inter-DnaA interactions are required for the unwinding-specific subcomplex. Significance: Differentiation of the unwinding-specific subcomplex and a key mechanism underlying it are revealed.

Original languageEnglish
Pages (from-to)37458-37471
Number of pages14
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
Publication statusPublished - Oct 26 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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