Differing Distribution of Hepatocyte Growth Factor‐positive Cells in the Liver of LEC Rats with Acute Hepatitis, Chronic Hepatitis and Hepatoma

Nobuaki Nakayama, Haruhiko Kashiwazaki, Narumi Kobayashi, Jun‐ichi ‐i Hamada, Kunio Matsumoto, Toshikazu Nakamura, Noritoshi Takeichi

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13 Citations (Scopus)

Abstract

Using anti‐rat hepatocyte growth factor (HGF) antibody, we investigated the distribution of HGF‐positive cells in the liver tissues of LEC rats at various phases of liver diseases. During the phase of fulminant hepatitis, HGF‐positive cells increased remarkably, and many of them were localized at the portal triads; these cells were identified from their shape as non‐epithelial cells. A reduced number of HGF‐positive cells was observed during the phase of chronic hepatitis, while no HGF‐positive cells were seen in the tissue of cholangiofibrosis. During the phase of carcinoma, staining revealed that both the hepatocellular carcinoma cells and the non‐epithelial cells in cancerous liver tissue were HGF‐positive. These results suggest that, in LEC rats, HGF may play an important role in the regeneration of hepatocytes as well as in the development of hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalJapanese Journal of Cancer Research
Volume86
Issue number1
DOIs
Publication statusPublished - Jan 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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