Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma

Koji Kato; Toshihiro Miyamoto; Akihiko Numata; Takashi Nakaike; Hideyo Oka; Ayano Yurino; Takuro Kuriyama; Yasuo Mori; Satoshi Yamasaki; Tsuyoshi Muta; Katsuto Takenaka; Hiromi Iwasaki; Takanori Teshima; Koichi Akashi

doi:10.1007/s12185-013-1278-z

Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma

Koji Kato, Toshihiro Miyamoto, Akihiko Numata, Takashi Nakaike, Hideyo Oka, Ayano Yurino, Takuro Kuriyama, Yasuo Mori, Satoshi Yamasaki, Tsuyoshi Muta, Katsuto Takenaka, Hiromi Iwasaki, Takanori Teshima, Koichi Akashi

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We present the case of a 62-year-old Japanese woman with relapsed adult T-cell leukemia/lymphoma (ATLL) who was treated with humanized anti-CCR4 monoclonal antibody (KW-0761). Although this antibody was highly effective against refractory ATLL, 6 months after the final KW-0761 infusion, the patient complained of hypoxia due to diffuse panbronchiolitis. Physicians should remain vigilant to the possibility of such previously unreported late-onset adverse effects associated with KW-0761 therapy.

Original language	English
Pages (from-to)	430-432
Number of pages	3
Journal	International journal of hematology
Volume	97
Issue number	3
DOIs	https://doi.org/10.1007/s12185-013-1278-z
Publication status	Published - Mar 2013

All Science Journal Classification (ASJC) codes

Hematology

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Kato, K., Miyamoto, T., Numata, A., Nakaike, T., Oka, H., Yurino, A., Kuriyama, T., Mori, Y., Yamasaki, S., Muta, T., Takenaka, K., Iwasaki, H., Teshima, T., & Akashi, K. (2013). Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma. International journal of hematology, 97(3), 430-432. https://doi.org/10.1007/s12185-013-1278-z

Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma. / Kato, Koji ; Miyamoto, Toshihiro ; Numata, Akihiko; Nakaike, Takashi; Oka, Hideyo; Yurino, Ayano; Kuriyama, Takuro; Mori, Yasuo ; Yamasaki, Satoshi; Muta, Tsuyoshi; Takenaka, Katsuto; Iwasaki, Hiromi; Teshima, Takanori; Akashi, Koichi.

In: International journal of hematology, Vol. 97, No. 3, 03.2013, p. 430-432.

Research output: Contribution to journal › Article › peer-review

Kato, K , Miyamoto, T , Numata, A, Nakaike, T, Oka, H, Yurino, A, Kuriyama, T, Mori, Y , Yamasaki, S, Muta, T, Takenaka, K, Iwasaki, H, Teshima, T & Akashi, K 2013, 'Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma', International journal of hematology, vol. 97, no. 3, pp. 430-432. https://doi.org/10.1007/s12185-013-1278-z

Kato, Koji ; Miyamoto, Toshihiro ; Numata, Akihiko ; Nakaike, Takashi ; Oka, Hideyo ; Yurino, Ayano ; Kuriyama, Takuro ; Mori, Yasuo ; Yamasaki, Satoshi ; Muta, Tsuyoshi ; Takenaka, Katsuto ; Iwasaki, Hiromi ; Teshima, Takanori ; Akashi, Koichi. / Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma. In: International journal of hematology. 2013 ; Vol. 97, No. 3. pp. 430-432.

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abstract = "We present the case of a 62-year-old Japanese woman with relapsed adult T-cell leukemia/lymphoma (ATLL) who was treated with humanized anti-CCR4 monoclonal antibody (KW-0761). Although this antibody was highly effective against refractory ATLL, 6 months after the final KW-0761 infusion, the patient complained of hypoxia due to diffuse panbronchiolitis. Physicians should remain vigilant to the possibility of such previously unreported late-onset adverse effects associated with KW-0761 therapy.",

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AU - Oka, Hideyo

AU - Yurino, Ayano

AU - Kuriyama, Takuro

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AU - Yamasaki, Satoshi

AU - Muta, Tsuyoshi

AU - Takenaka, Katsuto

AU - Iwasaki, Hiromi

AU - Teshima, Takanori

AU - Akashi, Koichi

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Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma

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