Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma

Koji Kato; Toshihiro Miyamoto; Akihiko Numata; Takashi Nakaike; Hideyo Oka; Ayano Yurino; Takuro Kuriyama; Yasuo Mori; Satoshi Yamasaki; Tsuyoshi Muta; Katsuto Takenaka; Hiromi Iwasaki; Takanori Teshima; Koichi Akashi

doi:10.1007/s12185-013-1278-z

Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma

Koji Kato, Toshihiro Miyamoto, Akihiko Numata, Takashi Nakaike, Hideyo Oka, Ayano Yurino, Takuro Kuriyama, Yasuo Mori, Satoshi Yamasaki, Tsuyoshi Muta, Katsuto Takenaka, Hiromi Iwasaki, Takanori Teshima, Koichi Akashi

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10 Citations (Scopus)

Abstract

We present the case of a 62-year-old Japanese woman with relapsed adult T-cell leukemia/lymphoma (ATLL) who was treated with humanized anti-CCR4 monoclonal antibody (KW-0761). Although this antibody was highly effective against refractory ATLL, 6 months after the final KW-0761 infusion, the patient complained of hypoxia due to diffuse panbronchiolitis. Physicians should remain vigilant to the possibility of such previously unreported late-onset adverse effects associated with KW-0761 therapy.

Original language	English
Pages (from-to)	430-432
Number of pages	3
Journal	International journal of hematology
Volume	97
Issue number	3
DOIs	https://doi.org/10.1007/s12185-013-1278-z
Publication status	Published - Mar 2013

All Science Journal Classification (ASJC) codes

Hematology

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Kato, K., Miyamoto, T., Numata, A., Nakaike, T., Oka, H., Yurino, A., Kuriyama, T., Mori, Y., Yamasaki, S., Muta, T., Takenaka, K., Iwasaki, H., Teshima, T., & Akashi, K. (2013). Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma. International journal of hematology, 97(3), 430-432. https://doi.org/10.1007/s12185-013-1278-z

Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma. / Kato, Koji; Miyamoto, Toshihiro; Numata, Akihiko; Nakaike, Takashi; Oka, Hideyo; Yurino, Ayano; Kuriyama, Takuro; Mori, Yasuo ; Yamasaki, Satoshi; Muta, Tsuyoshi; Takenaka, Katsuto; Iwasaki, Hiromi; Teshima, Takanori; Akashi, Koichi.

In: International journal of hematology, Vol. 97, No. 3, 03.2013, p. 430-432.

Research output: Contribution to journal › Article › peer-review

Kato, K, Miyamoto, T, Numata, A, Nakaike, T, Oka, H, Yurino, A, Kuriyama, T, Mori, Y , Yamasaki, S, Muta, T, Takenaka, K, Iwasaki, H, Teshima, T & Akashi, K 2013, 'Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma', International journal of hematology, vol. 97, no. 3, pp. 430-432. https://doi.org/10.1007/s12185-013-1278-z

Kato, Koji ; Miyamoto, Toshihiro ; Numata, Akihiko ; Nakaike, Takashi ; Oka, Hideyo ; Yurino, Ayano ; Kuriyama, Takuro ; Mori, Yasuo ; Yamasaki, Satoshi ; Muta, Tsuyoshi ; Takenaka, Katsuto ; Iwasaki, Hiromi ; Teshima, Takanori ; Akashi, Koichi. / Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma. In: International journal of hematology. 2013 ; Vol. 97, No. 3. pp. 430-432.

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abstract = "We present the case of a 62-year-old Japanese woman with relapsed adult T-cell leukemia/lymphoma (ATLL) who was treated with humanized anti-CCR4 monoclonal antibody (KW-0761). Although this antibody was highly effective against refractory ATLL, 6 months after the final KW-0761 infusion, the patient complained of hypoxia due to diffuse panbronchiolitis. Physicians should remain vigilant to the possibility of such previously unreported late-onset adverse effects associated with KW-0761 therapy.",

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AU - Oka, Hideyo

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Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma

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