TY - JOUR
T1 - Diffusion tensor imaging the medial longitudinal fasciculus in INO
T2 - Opportunities and challenges
AU - Sakaie, Ken
AU - Takahashi, Masaya
AU - Dimitrov, Ivan
AU - Togao, Osamu
AU - Davis, Scott
AU - Remington, Gina
AU - Conger, Amy
AU - Conger, Darrel
AU - Frohman, Teresa
AU - Fox, Robert
AU - Frohman, Elliot
PY - 2011/1/1
Y1 - 2011/1/1
N2 - The medial longitudinal fasciculus (MLF) is a white matter pathway in the brainstem that plays a key role in coordinating eye movements. Injury to the MLF leads to abnormalities in eye movements that can be measured with high precision by oculography, making it an ideal eloquent pathway to study imaging/function correlates. Tractography is an emerging method for identifying white matter pathways and offers the tantalizing promise of noninvasive, quantitative characterization of tissue integrity underlying functional deficits. However, the small caliber of the MLF and partial volume averaging with signal from nearby cerebrospinal fluid pose severe technical challenges to tractography-based delineation of the MLF. We discuss progress toward the goal of imaging the MLF and potential benefits of achieving this goal. Initial work suggests that ultra-high field (7 tesla) may complement tractography for characterizing the MLF.
AB - The medial longitudinal fasciculus (MLF) is a white matter pathway in the brainstem that plays a key role in coordinating eye movements. Injury to the MLF leads to abnormalities in eye movements that can be measured with high precision by oculography, making it an ideal eloquent pathway to study imaging/function correlates. Tractography is an emerging method for identifying white matter pathways and offers the tantalizing promise of noninvasive, quantitative characterization of tissue integrity underlying functional deficits. However, the small caliber of the MLF and partial volume averaging with signal from nearby cerebrospinal fluid pose severe technical challenges to tractography-based delineation of the MLF. We discuss progress toward the goal of imaging the MLF and potential benefits of achieving this goal. Initial work suggests that ultra-high field (7 tesla) may complement tractography for characterizing the MLF.
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U2 - 10.1111/j.1749-6632.2011.06156.x
DO - 10.1111/j.1749-6632.2011.06156.x
M3 - Article
C2 - 21951009
AN - SCOPUS:80053214811
SN - 0077-8923
VL - 1233
SP - 307
EP - 312
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
IS - 1
ER -