Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis

Yoshimitsu Ohgiya, Masaki Oka, Akio Hiwatashi, Xiang Liu, Naoya Kakimoto, Per Lennart A. Westesson, Sven E. Ekholm

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Abstract

Our purpose was to evaluate the ability of diffusion tensor imaging (DTI) to characterize cervical spinal cord white matter (WM) in patients with multiple sclerosis (MS). DTI were obtained in 21 MS patients and 21 control subjects (CS). Regions of interest (ROIs) were placed at C2/3, C3/4, and C4/5 within the right, left, and dorsal (WM) to calculate fractional anisotropy (FA) and the apparent diffusion coefficient (ADC). Measurements in plaques and normal-appearing white matter (NAWM) of MS patients were compared with mean FA and ADC of WM in CS. FA was significantly lower in all regions in MS patients than in CS. ADC was significantly higher in all regions in MS patients than in CS except for in the dorsal WM at C2/3 and the bilateral WM at C4/5. The mean FA was 0.441 for plaques and 0.542 for NAWM, as compared with 0.739 in CS. The mean ADC was 0.810×10-3 mm2/s for plaques and 0.722×10-3 mm2/s for NAWM, as compared with 0.640×10-3 mm2/s for CS. FA and ADC showed significant differences between plaques, NAWM and control WM(P<0.01).

Original languageEnglish
Pages (from-to)2499-2504
Number of pages6
JournalEuropean Radiology
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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    Ohgiya, Y., Oka, M., Hiwatashi, A., Liu, X., Kakimoto, N., Westesson, P. L. A., & Ekholm, S. E. (2007). Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis. European Radiology, 17(10), 2499-2504. https://doi.org/10.1007/s00330-007-0672-4