Diffusion-weighted echo-planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses: Usefulness of detecting keratinoid substances in mature cystic teratomas

Tomohiro Nakayama, Kengo Yoshimitsu, Hiroyuki Irie, Hitoshi Aibe, Tsuyoshi Tajima, Akihiro Nishie, Yoshiki Asayama, Kunishige Matake, Daisuke Kakihara, Shuji Matsuura, Hitoo Nakano, Hiroshi Honda

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Purpose: To elucidate whether apparent diffusion coefficient (ADC) values calculated from echo-planar diffusion-weighted MR imaging (EPDWI) are useful in the differential diagnosis of ovarian cystic masses. Materials and Methods: EPDWI was performed in 131 patients with ovarian cystic masses (54 mature cystic teratomas, 35 endometrial cysts, four other benign cysts, 14 benign neoplasms, and 24 malignant neoplasms). The areas of the highest signal intensity on EPDWI (b = 1000 seconds/mm2) and the lowest ADC values within the cystic component were evaluated. Results: On qualitative and quantitative analyses, mature cystic teratomas tended to show higher signal intensity and had areas of lower ADC values than endometrial cysts and other benign and malignant neoplasms (P < .005). In vitro scanning of the cystic contents of mature cystic teratomas confirmed that high signal on DWI or low ADC value was attributable to the keratinoid substance within the tumors. The difference in ADC between malignant and benign lesions were significant when mature cystic teratomas and endometrial cysts were included, but was not significant when they were excluded. Conclusion: The ADC value may add useful information to the differential diagnosis of ovarian cystic masses in limited populations, such as those with mature cystic teratomas with a small amount of fat.

Original languageEnglish
Pages (from-to)271-278
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume22
Issue number2
DOIs
Publication statusPublished - Aug 1 2005

Fingerprint

Echo-Planar Imaging
Teratoma
Differential Diagnosis
Cysts
Neoplasms
Fats

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Diffusion-weighted echo-planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses : Usefulness of detecting keratinoid substances in mature cystic teratomas. / Nakayama, Tomohiro; Yoshimitsu, Kengo; Irie, Hiroyuki; Aibe, Hitoshi; Tajima, Tsuyoshi; Nishie, Akihiro; Asayama, Yoshiki; Matake, Kunishige; Kakihara, Daisuke; Matsuura, Shuji; Nakano, Hitoo; Honda, Hiroshi.

In: Journal of Magnetic Resonance Imaging, Vol. 22, No. 2, 01.08.2005, p. 271-278.

Research output: Contribution to journalArticle

Nakayama, Tomohiro ; Yoshimitsu, Kengo ; Irie, Hiroyuki ; Aibe, Hitoshi ; Tajima, Tsuyoshi ; Nishie, Akihiro ; Asayama, Yoshiki ; Matake, Kunishige ; Kakihara, Daisuke ; Matsuura, Shuji ; Nakano, Hitoo ; Honda, Hiroshi. / Diffusion-weighted echo-planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses : Usefulness of detecting keratinoid substances in mature cystic teratomas. In: Journal of Magnetic Resonance Imaging. 2005 ; Vol. 22, No. 2. pp. 271-278.
@article{81b3f9d6467745d29bb9af014ba76124,
title = "Diffusion-weighted echo-planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses: Usefulness of detecting keratinoid substances in mature cystic teratomas",
abstract = "Purpose: To elucidate whether apparent diffusion coefficient (ADC) values calculated from echo-planar diffusion-weighted MR imaging (EPDWI) are useful in the differential diagnosis of ovarian cystic masses. Materials and Methods: EPDWI was performed in 131 patients with ovarian cystic masses (54 mature cystic teratomas, 35 endometrial cysts, four other benign cysts, 14 benign neoplasms, and 24 malignant neoplasms). The areas of the highest signal intensity on EPDWI (b = 1000 seconds/mm2) and the lowest ADC values within the cystic component were evaluated. Results: On qualitative and quantitative analyses, mature cystic teratomas tended to show higher signal intensity and had areas of lower ADC values than endometrial cysts and other benign and malignant neoplasms (P < .005). In vitro scanning of the cystic contents of mature cystic teratomas confirmed that high signal on DWI or low ADC value was attributable to the keratinoid substance within the tumors. The difference in ADC between malignant and benign lesions were significant when mature cystic teratomas and endometrial cysts were included, but was not significant when they were excluded. Conclusion: The ADC value may add useful information to the differential diagnosis of ovarian cystic masses in limited populations, such as those with mature cystic teratomas with a small amount of fat.",
author = "Tomohiro Nakayama and Kengo Yoshimitsu and Hiroyuki Irie and Hitoshi Aibe and Tsuyoshi Tajima and Akihiro Nishie and Yoshiki Asayama and Kunishige Matake and Daisuke Kakihara and Shuji Matsuura and Hitoo Nakano and Hiroshi Honda",
year = "2005",
month = "8",
day = "1",
doi = "10.1002/jmri.20369",
language = "English",
volume = "22",
pages = "271--278",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Diffusion-weighted echo-planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses

T2 - Usefulness of detecting keratinoid substances in mature cystic teratomas

AU - Nakayama, Tomohiro

AU - Yoshimitsu, Kengo

AU - Irie, Hiroyuki

AU - Aibe, Hitoshi

AU - Tajima, Tsuyoshi

AU - Nishie, Akihiro

AU - Asayama, Yoshiki

AU - Matake, Kunishige

AU - Kakihara, Daisuke

AU - Matsuura, Shuji

AU - Nakano, Hitoo

AU - Honda, Hiroshi

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Purpose: To elucidate whether apparent diffusion coefficient (ADC) values calculated from echo-planar diffusion-weighted MR imaging (EPDWI) are useful in the differential diagnosis of ovarian cystic masses. Materials and Methods: EPDWI was performed in 131 patients with ovarian cystic masses (54 mature cystic teratomas, 35 endometrial cysts, four other benign cysts, 14 benign neoplasms, and 24 malignant neoplasms). The areas of the highest signal intensity on EPDWI (b = 1000 seconds/mm2) and the lowest ADC values within the cystic component were evaluated. Results: On qualitative and quantitative analyses, mature cystic teratomas tended to show higher signal intensity and had areas of lower ADC values than endometrial cysts and other benign and malignant neoplasms (P < .005). In vitro scanning of the cystic contents of mature cystic teratomas confirmed that high signal on DWI or low ADC value was attributable to the keratinoid substance within the tumors. The difference in ADC between malignant and benign lesions were significant when mature cystic teratomas and endometrial cysts were included, but was not significant when they were excluded. Conclusion: The ADC value may add useful information to the differential diagnosis of ovarian cystic masses in limited populations, such as those with mature cystic teratomas with a small amount of fat.

AB - Purpose: To elucidate whether apparent diffusion coefficient (ADC) values calculated from echo-planar diffusion-weighted MR imaging (EPDWI) are useful in the differential diagnosis of ovarian cystic masses. Materials and Methods: EPDWI was performed in 131 patients with ovarian cystic masses (54 mature cystic teratomas, 35 endometrial cysts, four other benign cysts, 14 benign neoplasms, and 24 malignant neoplasms). The areas of the highest signal intensity on EPDWI (b = 1000 seconds/mm2) and the lowest ADC values within the cystic component were evaluated. Results: On qualitative and quantitative analyses, mature cystic teratomas tended to show higher signal intensity and had areas of lower ADC values than endometrial cysts and other benign and malignant neoplasms (P < .005). In vitro scanning of the cystic contents of mature cystic teratomas confirmed that high signal on DWI or low ADC value was attributable to the keratinoid substance within the tumors. The difference in ADC between malignant and benign lesions were significant when mature cystic teratomas and endometrial cysts were included, but was not significant when they were excluded. Conclusion: The ADC value may add useful information to the differential diagnosis of ovarian cystic masses in limited populations, such as those with mature cystic teratomas with a small amount of fat.

UR - http://www.scopus.com/inward/record.url?scp=22944473055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22944473055&partnerID=8YFLogxK

U2 - 10.1002/jmri.20369

DO - 10.1002/jmri.20369

M3 - Article

C2 - 16028258

AN - SCOPUS:22944473055

VL - 22

SP - 271

EP - 278

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 2

ER -