Difluoro-C4′-oxidized abasic site for efficient amine modification in biological systems

Bo Yang, Akiko Jinnouchi, Hiroshi Suemune, Mariko Aso

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An oligodeoxynucleotide (ODN) containing a 2′,2′-difluorinated analogue of a C4′-oxidized abasic site (C4′-OAS) was designed for the amine modification of biomolecules that interact with nucleic acids. In contrast to the parent C4′-OAS, which yielded amine-modified products accompanied by DNA strand scission, the ODN containing the difluoro C4′-OAS efficiently yielded products carrying ODNs. The amine modification proceeded without additional reagents being required and might be applicable to reactions in biological systems.

Original languageEnglish
Pages (from-to)5852-5855
Number of pages4
JournalOrganic Letters
Volume14
Issue number23
DOIs
Publication statusPublished - Dec 7 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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