Dilation of the brachial artery in response to sublingual nitroglycerin can predict the antihypertensive effects of valsartan: A study using novel high-frequency high-frame-rate ultrasound imaging

Mamiko Inoue, Satoshi Fujii, Taisei Mikami, Tomoo Furumoto, Sanae Kaga, Hiroshi Komatsu, Kazutomo Goto, Kaoru Komuro, Satoshi Yamada, Hisao Onozuka, Akira Kitabatake, Hiroyuki Tsutsui

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives. The efficacy of antihypertensive agents can vary in patients. Four to 8 weeks may be required before antihypertensive agents become fully effective. Predicting the efficacy can help agent selection and dose setting. This study determined whether nitroglycerin-induced vasodilation of brachial arteries can predict the antihypertensive action of angiotensin II receptor antagonist. Methods. Untreated uncomplicated patients with essential hypertension, who gave informed consent, were studied (n = 20, mean age 55 years). Before antihypertensive treatment, nitroglycerin-induced vasodilation of the brachial arteries was measured using a novel method of 15 MHz high-frequency high-frame-rate ultrasound imaging (Hitachi EUB8000). Diameter of the brachial artery at the end-systolic phase was measured before and after 0.3 mg nitroglycerin sublingual spray and percentage vasodilation (%D-N) was calculated. The reduction of mean blood pressure after nitroglycerin (%BP-N) was calculated. Valsartan monotherapy (40-80 mg/day) was administered for 3-6 months (mean 132 days). Reduction of mean blood pressure after valsartan monotherapy (%BP-V) was calculated. Results. Valsartan decreased systolic blood pressure from 138 ± 13 to 130 ± 17mmHg, and diastolic blood pressure from 83 ± 11 to 78 ± 11 mmHg (p < 0.05). %D-N was correlated closely with %BP-V (r = -0.70, p < 0.001). %BP-N had no correlation with %BP-V (r = 0.13, p = 0.58). Conclusions. Direct vasodilatory action of nitroglycerin on vascular smooth muscle cells may predict the chronic antihypertensive effect of angiotensin II receptor antagonist.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalJournal of Cardiology
Volume47
Issue number1
Publication statusPublished - 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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