Dimensions of temperament as vulnerability factors in depression

Y. Ono, J. Ando, N. Onoda, K. Yoshimura, T. Momose, M. Hirano, Shigenobu Kanba

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

In order to evaluate the hypothesis that one set of genetic risk factors may be common to disorders and dimensions of temperament, whereas environmental risk factors are disorder specific, we have conducted a genetic analysis of dimensions of temperament and symptoms of depression in about 201 pairs of monozygotic and dizygotic twins. Dimensions of temperament associated with novelty seeking, harm avoidance, reward dependence, and persistence were measured by using the Temperament and Character Instruments developed by Cloninger, and depressive symptoms were measured using the Hospital Anxiety and Depression Scale. Differences among individuals on these measures can be explained by differences in their genes and in their environmental experiences. There are no differences between the sexes in gene action affecting temperament. Each dimension of temperament is genetically dependent, and genetic variations in symptoms of depression are largely dependent on the same factors that affect the temperament. Temperament is closely associated with vulnerability to depressive symptoms.

Original languageEnglish
Pages (from-to)948-953
Number of pages6
JournalMolecular Psychiatry
Volume7
Issue number9
DOIs
Publication statusPublished - Jan 1 2002
Externally publishedYes

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Temperament
Depression
Dizygotic Twins
Monozygotic Twins
Reward
Individuality
Sex Characteristics
Genes
Anxiety

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Ono, Y., Ando, J., Onoda, N., Yoshimura, K., Momose, T., Hirano, M., & Kanba, S. (2002). Dimensions of temperament as vulnerability factors in depression. Molecular Psychiatry, 7(9), 948-953. https://doi.org/10.1038/sj.mp.4001122

Dimensions of temperament as vulnerability factors in depression. / Ono, Y.; Ando, J.; Onoda, N.; Yoshimura, K.; Momose, T.; Hirano, M.; Kanba, Shigenobu.

In: Molecular Psychiatry, Vol. 7, No. 9, 01.01.2002, p. 948-953.

Research output: Contribution to journalArticle

Ono, Y, Ando, J, Onoda, N, Yoshimura, K, Momose, T, Hirano, M & Kanba, S 2002, 'Dimensions of temperament as vulnerability factors in depression', Molecular Psychiatry, vol. 7, no. 9, pp. 948-953. https://doi.org/10.1038/sj.mp.4001122
Ono Y, Ando J, Onoda N, Yoshimura K, Momose T, Hirano M et al. Dimensions of temperament as vulnerability factors in depression. Molecular Psychiatry. 2002 Jan 1;7(9):948-953. https://doi.org/10.1038/sj.mp.4001122
Ono, Y. ; Ando, J. ; Onoda, N. ; Yoshimura, K. ; Momose, T. ; Hirano, M. ; Kanba, Shigenobu. / Dimensions of temperament as vulnerability factors in depression. In: Molecular Psychiatry. 2002 ; Vol. 7, No. 9. pp. 948-953.
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