Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases

Yoshiaki Shinden, Sayuri Akiyoshi, Hiroki Ueo, Syo Nambara, Tomoko Saito, Hisateru Komatsu, Masami Ueda, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Yuki Takano, Tomohiro Iguchi, Hidetoshi Eguchi, Keishi Sugimachi, Yuko Kijima, Hiroaki Ueo, Shoji Natsugoe, Koshi Mimori

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Abstract

Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.

Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.

Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].

Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalAnticancer research
Volume35
Issue number1
Publication statusPublished - Jan 1 2015

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Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasms
Cyclins
Disease-Free Survival
Cell Cycle
Multivariate Analysis
Biomarkers
Cell Proliferation
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Shinden, Y., Akiyoshi, S., Ueo, H., Nambara, S., Saito, T., Komatsu, H., ... Mimori, K. (2015). Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases. Anticancer research, 35(1), 123-128.

Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases. / Shinden, Yoshiaki; Akiyoshi, Sayuri; Ueo, Hiroki; Nambara, Syo; Saito, Tomoko; Komatsu, Hisateru; Ueda, Masami; Hirata, Hidenari; Sakimura, Shotaro; Uchi, Ryutaro; Takano, Yuki; Iguchi, Tomohiro; Eguchi, Hidetoshi; Sugimachi, Keishi; Kijima, Yuko; Ueo, Hiroaki; Natsugoe, Shoji; Mimori, Koshi.

In: Anticancer research, Vol. 35, No. 1, 01.01.2015, p. 123-128.

Research output: Contribution to journalArticle

Shinden, Y, Akiyoshi, S, Ueo, H, Nambara, S, Saito, T, Komatsu, H, Ueda, M, Hirata, H, Sakimura, S, Uchi, R, Takano, Y, Iguchi, T, Eguchi, H, Sugimachi, K, Kijima, Y, Ueo, H, Natsugoe, S & Mimori, K 2015, 'Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases', Anticancer research, vol. 35, no. 1, pp. 123-128.
Shinden Y, Akiyoshi S, Ueo H, Nambara S, Saito T, Komatsu H et al. Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases. Anticancer research. 2015 Jan 1;35(1):123-128.
Shinden, Yoshiaki ; Akiyoshi, Sayuri ; Ueo, Hiroki ; Nambara, Syo ; Saito, Tomoko ; Komatsu, Hisateru ; Ueda, Masami ; Hirata, Hidenari ; Sakimura, Shotaro ; Uchi, Ryutaro ; Takano, Yuki ; Iguchi, Tomohiro ; Eguchi, Hidetoshi ; Sugimachi, Keishi ; Kijima, Yuko ; Ueo, Hiroaki ; Natsugoe, Shoji ; Mimori, Koshi. / Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases. In: Anticancer research. 2015 ; Vol. 35, No. 1. pp. 123-128.
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abstract = "Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.",
author = "Yoshiaki Shinden and Sayuri Akiyoshi and Hiroki Ueo and Syo Nambara and Tomoko Saito and Hisateru Komatsu and Masami Ueda and Hidenari Hirata and Shotaro Sakimura and Ryutaro Uchi and Yuki Takano and Tomohiro Iguchi and Hidetoshi Eguchi and Keishi Sugimachi and Yuko Kijima and Hiroaki Ueo and Shoji Natsugoe and Koshi Mimori",
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AU - Shinden, Yoshiaki

AU - Akiyoshi, Sayuri

AU - Ueo, Hiroki

AU - Nambara, Syo

AU - Saito, Tomoko

AU - Komatsu, Hisateru

AU - Ueda, Masami

AU - Hirata, Hidenari

AU - Sakimura, Shotaro

AU - Uchi, Ryutaro

AU - Takano, Yuki

AU - Iguchi, Tomohiro

AU - Eguchi, Hidetoshi

AU - Sugimachi, Keishi

AU - Kijima, Yuko

AU - Ueo, Hiroaki

AU - Natsugoe, Shoji

AU - Mimori, Koshi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.

AB - Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.

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