Abstract
Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.
Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.
Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].
Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.
| Original language | English |
|---|---|
| Pages (from-to) | 123-128 |
| Number of pages | 6 |
| Journal | Anticancer research |
| Volume | 35 |
| Issue number | 1 |
| Publication status | Published - Jan 1 2015 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases. / Shinden, Yoshiaki; Akiyoshi, Sayuri; Ueo, Hiroki; Nambara, Syo; Saito, Tomoko; Komatsu, Hisateru; Ueda, Masami; Hirata, Hidenari; Sakimura, Shotaro; Uchi, Ryutaro; Takano, Yuki; Iguchi, Tomohiro; Eguchi, Hidetoshi; Sugimachi, Keishi; Kijima, Yuko; Ueo, Hiroaki; Natsugoe, Shoji; Mimori, Koshi.
In: Anticancer research, Vol. 35, No. 1, 01.01.2015, p. 123-128.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases
AU - Shinden, Yoshiaki
AU - Akiyoshi, Sayuri
AU - Ueo, Hiroki
AU - Nambara, Syo
AU - Saito, Tomoko
AU - Komatsu, Hisateru
AU - Ueda, Masami
AU - Hirata, Hidenari
AU - Sakimura, Shotaro
AU - Uchi, Ryutaro
AU - Takano, Yuki
AU - Iguchi, Tomohiro
AU - Eguchi, Hidetoshi
AU - Sugimachi, Keishi
AU - Kijima, Yuko
AU - Ueo, Hiroaki
AU - Natsugoe, Shoji
AU - Mimori, Koshi
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.
AB - Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.
UR - http://www.scopus.com/inward/record.url?scp=84920460491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920460491&partnerID=8YFLogxK
M3 - Article
C2 - 25550542
AN - SCOPUS:84920460491
VL - 35
SP - 123
EP - 128
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 1
ER -