Dipyridamole inhibits early wound healing in rat skin incisions

Hiroyuki Kuwano, Kazuhiro Yano, Shinji Ohno, Masahiko Ikebe, Kaoru Kitamura, Yasushi Toh, Masaki Mori, Keizo Sugimachi

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Abstract

In an effort to investigate the significance of platelet aggregation on early wound healing, the inhibitory effects of an antiplatelet drug (dipyridamole) on tensile wound strength was assessed. The breaking strength of the dorsal incisional wounds in Donryu rats both with and without the administration of dipyridamole was measured. In experiment I, the intraperitoneal administration of dipyridamole (100 mg/kg/day, Group A; 50 mg/kg/day, Group B) and saline (3 ml/day; Group C) was performed during the periods between the day of incision and the excision of the healing wound specimen in a 2.0-cm width on the third and seventh postoperative days (POD). The wound breaking strength was 229 ± 44, 256 ± 39, and 352 ± 38 g/cm2 on POD 3 and 477 ± 67,578 ± 60, and 764 ± 31.9 g/cm2 on POD 7, in Groups A, B, and C, respectively. In experiment II, we performed the intraperitoneal administration of either dipyridamole (100 mg/kg) or 3 ml of saline as a control just before incision (Group a) as well as at 4 hr (Group b), and 12 hr (Group c) after incision, and the percentages of tensile strength compared with the control were 72 ± 8, 89 ± 13, and 103 ± 23% in Groups a, b, and c, respectively. The administration of dipyridamole significantly inhibited the wound healing and, therefore, platelet aggregation would appear to play an important role in the early phase of wound healing.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalJournal of Surgical Research
Volume56
Issue number3
DOIs
Publication statusPublished - Mar 1994

All Science Journal Classification (ASJC) codes

  • Surgery

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    Kuwano, H., Yano, K., Ohno, S., Ikebe, M., Kitamura, K., Toh, Y., Mori, M., & Sugimachi, K. (1994). Dipyridamole inhibits early wound healing in rat skin incisions. Journal of Surgical Research, 56(3), 267-270. https://doi.org/10.1006/jsre.1994.1042