Direct catalytic asymmetric mannich-type reaction of thioamides

Yuta Suzuki, Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Taking the reins: The title transformation of thioamides and N-diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme). Divergent transformation of the thioamide functionality highlights the utility of this methodology.

Original languageEnglish
Pages (from-to)5026-5029
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number27
DOIs
Publication statusPublished - Jun 22 2009
Externally publishedYes

Fingerprint

Thioamides
Catalysis
Carbon
Acids
Lewis Acids
Imines

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Direct catalytic asymmetric mannich-type reaction of thioamides. / Suzuki, Yuta; Yazaki, Ryo; Kumagai, Naoya; Shibasaki, Masakatsu.

In: Angewandte Chemie - International Edition, Vol. 48, No. 27, 22.06.2009, p. 5026-5029.

Research output: Contribution to journalArticle

Suzuki, Yuta ; Yazaki, Ryo ; Kumagai, Naoya ; Shibasaki, Masakatsu. / Direct catalytic asymmetric mannich-type reaction of thioamides. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 27. pp. 5026-5029.
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