Direct use of allylic alcohols for platinum-catalyzed monoallylation of amines

Masaru Utsunomiya, Yoshiki Miyamoto, Junji Lpposhi, Takashi Ohshima, Kazushi Mashima

Research output: Contribution to journalArticlepeer-review

107 Citations (Scopus)

Abstract

A new direct catalytic amination of allylic alcohols promoted by the combination of platinum and a large bite-angle ligand DPEphos was developed in which the allylic alcohol was effectively converted to a π-allylplatinum intermediate without the use of an activating reagent. The use of the DPEphos ligand was essential for obtaining high catalyst activity and high monoallylation selectivity of primary amines, allowing the formation of a variety of monoallylation products in good to excellent yield.

Original languageEnglish
Pages (from-to)3371-3374
Number of pages4
JournalOrganic Letters
Volume9
Issue number17
DOIs
Publication statusPublished - Aug 16 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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