Discrete and ultradiscrete models for biological rhythms comprising a simple negative feedback loop

Shingo Gibo, Hiroshi Ito

Research output: Contribution to journalArticle

Abstract

Many biological rhythms are generated by negative feedback regulation. Griffith (1968) proved that a negative feedback model with two variables expressed by ordinary differential equations do not generate self-sustained oscillations. Kurosawa et al. (2002) expanded Griffith's result to the general type of negative feedback model with two variables. In this paper, we propose discrete and ultradiscrete feedback models with two variables that exhibit self-sustained oscillations. To obtain the model, we applied tropical discretization and ultradiscretization to a continuous model with two variables and then investigated its bifurcation structures and the conditions of parameters for oscillations. We found that when the degradation rate of the variables is lower than their synthesis rate, the proposed models generate oscillations by Neimark-Sacker bifurcation. We further demonstrate that the ultradiscrete model can be reduced to a Boolean system under some conditions.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalJournal of Theoretical Biology
Volume378
DOIs
Publication statusPublished - Aug 7 2015

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biological rhythms
Negative Feedback
Feedback Loop
Periodicity
Feedback
oscillation
Oscillation
Model
Neimark-Sacker Bifurcation
Ordinary differential equations
Ordinary differential equation
Degradation
Bifurcation
Discretization
Synthesis
synthesis
degradation

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Discrete and ultradiscrete models for biological rhythms comprising a simple negative feedback loop. / Gibo, Shingo; Ito, Hiroshi.

In: Journal of Theoretical Biology, Vol. 378, 07.08.2015, p. 89-95.

Research output: Contribution to journalArticle

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