Discrimination of D-amino acids from L-amino acids using membrane impedance change

Hardwell Chibvongodze, Kenshi Hayashi, Kiyoshi Toko

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

SUMMARY There are methods used to test the optical purity of enantiomers; however, most of the simple methods are not precise and more complicated methods are better. As a result, these methods cannot be widely used for industrial purposes. The aim of this research is to design a sensor which can discriminate D-amino acids from L-amino acids. The designed sensor has chiral membranes and uses the technique of impedance change of these chiral membranes to discriminate the amino acids. Ve used a noisc-FFT (Fast Fourier Transform) technique to determine the membrane impedance. When an enantiomer membrane resides in a chiral environment, (E), diastereomeric interactions (E*-D) and (E*-L) are created, which may differ sufficiently in the arrangement of molecules of the membranes so as to permit the discrimination of optical substances due to the change in membrane characteristics. With increasing concentrations of the amino acids, the membrane resistance changes depended on the optical activity of the amino acids. The results suggest that the impedance changes of the chiral membrane with diastereomeric reaction can be used for the high-performance chemical sensor to measure the optical purity of different substances.

Original languageEnglish
Pages (from-to)1028-1033
Number of pages6
JournalIEICE Transactions on Electronics
VolumeE83-C
Issue number7
Publication statusPublished - Jul 2000

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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