Disease recurrence plays a minor role as a cause for retransplantation after living-donor liver transplantation for primary biliary cirrhosis: A multicenter study in Japan

Hiroto Egawa, Yasuni Nakanuma, Yoshihiko Maehara, Shinji Uemoto, Susumu Eguchi, Yoshinobu Sato, Ken Shirabe, Mitsuhisa Takatsuki, Akira Mori, Masakazu Yamamoto, Hirohito Tsubouchi

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Abstract

Aim: To clarify the role of disease recurrence as a cause of graft loss after living-donor liver transplantation (LDLT) for primary biliary cirrhosis (PBC), we investigated explant grafts, as well as the native liver and liver biopsy specimens, of patients who underwent retransplantation. Methods: Of 516 patients who underwent LDLT for PBC and were registered in the Japanese Liver Transplant Registry, nine patients (1.7%) underwent retransplantation. Results: Seven patients undergoing retransplantation later than 6 months after primary liver transplantation (LT) were enrolled. All seven patients were female, with ages ranging from 34-57 years, and Model for End-Stage Liver Disease scores ranging 10-28. The right lobe was used as graft in one and the left lobe in six. The initial immunosuppression regimen was tacrolimus in six and cyclosporin in one. The period between the primary LT and retransplantation ranged 11-120 months, with a median of 36 months. Three patients survived and four patients died due to poor graft functions or complications after retransplantation. The primary causes of primary graft loss revealed by histological examination of the explant livers were chronic rejection in three, portal thrombus and/or steatohepatitis in three and outflow block in one. PBC recurrence was observed in 3 and the stage was mild in all. Conclusion: PBC recurrence has a small impact as a cause of graft loss after LDLT.

Original languageEnglish
Pages (from-to)502-507
Number of pages6
JournalHepatology Research
Volume43
Issue number5
DOIs
Publication statusPublished - May 1 2013

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Biliary Liver Cirrhosis
Living Donors
Liver Transplantation
Multicenter Studies
Japan
Transplants
Recurrence
Liver
End Stage Liver Disease
Tacrolimus
Fatty Liver
Immunosuppression
Cyclosporine
Registries
Thrombosis
Biopsy

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

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Disease recurrence plays a minor role as a cause for retransplantation after living-donor liver transplantation for primary biliary cirrhosis : A multicenter study in Japan. / Egawa, Hiroto; Nakanuma, Yasuni; Maehara, Yoshihiko; Uemoto, Shinji; Eguchi, Susumu; Sato, Yoshinobu; Shirabe, Ken; Takatsuki, Mitsuhisa; Mori, Akira; Yamamoto, Masakazu; Tsubouchi, Hirohito.

In: Hepatology Research, Vol. 43, No. 5, 01.05.2013, p. 502-507.

Research output: Contribution to journalArticle

Egawa, H, Nakanuma, Y, Maehara, Y, Uemoto, S, Eguchi, S, Sato, Y, Shirabe, K, Takatsuki, M, Mori, A, Yamamoto, M & Tsubouchi, H 2013, 'Disease recurrence plays a minor role as a cause for retransplantation after living-donor liver transplantation for primary biliary cirrhosis: A multicenter study in Japan', Hepatology Research, vol. 43, no. 5, pp. 502-507. https://doi.org/10.1111/j.1872-034X.2012.01108.x
Egawa, Hiroto ; Nakanuma, Yasuni ; Maehara, Yoshihiko ; Uemoto, Shinji ; Eguchi, Susumu ; Sato, Yoshinobu ; Shirabe, Ken ; Takatsuki, Mitsuhisa ; Mori, Akira ; Yamamoto, Masakazu ; Tsubouchi, Hirohito. / Disease recurrence plays a minor role as a cause for retransplantation after living-donor liver transplantation for primary biliary cirrhosis : A multicenter study in Japan. In: Hepatology Research. 2013 ; Vol. 43, No. 5. pp. 502-507.
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AU - Shirabe, Ken

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