Disruption of clh-1, a chloride channel gene, results in a wider body of Caenorhabditis elegans

Mark I.R. Petalcorin, Toshihiko Oka, Makoto Koga, Ken Ichi Ogura, Yoh Wada, Yasumi Ohshima, Masamitsu Futai

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We cloned the clh-1 gene coding for a putative ClC chloride channel in Caenorhabditis elegans. The gene product exhibited a high degree of homology with human ClC-1 and ClC-2. The clh-1 gene was predominantly expressed in the hypodermis, including seam cells. Null mutations of clh-1 caused a significantly wider body and an abnormal alae structure. High osmolarity in the culture medium restored the normal body width of the clh-1 mutants. These results suggest that the clh-1 gene contributes to maintenance of the body width through regulation of osmolarity.

Original languageEnglish
Pages (from-to)347-355
Number of pages9
JournalJournal of Molecular Biology
Volume294
Issue number2
DOIs
Publication statusPublished - Nov 26 1999

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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