Disseminated bacillus calmette-guérin lymphadenitis in a patient with gp91phox - Chronic granulomatous disease 25 years after vaccination

Koichi Kusuhara, Shouichi Ohga, Takayuki Hoshina, Mitsumasa Saito, Yuka Sasaki, Masataka Ishimura, Hidetoshi Takada, Masaki Fujita, Toshiro Hara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A boy developed ipsilateral axillary lymphadenitis after Bacillus Calmette-Guérin (BCG) inoculation at the age of 5 months. Subsequently, he was diagnosed with X-linked chronic granulomatous disease (CGD) by the nitroblue tetrazolium assay when he was 4 years old. Body computerized tomography (CT) performed at the age of 25 years showed enlarged lymph nodes in the left periclavicular and axillary regions, and was confirmed by gallium scintigraphy. Mycobacterial culture, smear, and polymerase chain reaction (PCR) of the sputum and gastric fluid were negative. Whole-blood IFN-γ assay was negative as well. Mycobacterium bovis BCG was isolated from the lymph node biopsy by PCR amplification and culture. No mutation of the IFN-γ receptor 1 could be identified. In conclusion, CGD can be the underlying condition for BCG-itis; whole-blood IFN-γ assay might be useful in differentiating BCG infection and tuberculosis in CGD patients; BCG vaccination is contraindicated in X-linked CGD.

Original languageEnglish
Pages (from-to)745-747
Number of pages3
JournalEuropean Journal of Pediatrics
Volume168
Issue number6
DOIs
Publication statusPublished - Jun 1 2009

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Disseminated bacillus calmette-guérin lymphadenitis in a patient with gp91phox <sup>-</sup> Chronic granulomatous disease 25 years after vaccination'. Together they form a unique fingerprint.

  • Cite this