Disseminated bacillus calmette-guérin lymphadenitis in a patient with gp91phox - Chronic granulomatous disease 25 years after vaccination

Koichi Kusuhara, Shouichi Ohga, Takayuki Hoshina, Mitsumasa Saito, Yuka Sasaki, Masataka Ishimura, Hidetoshi Takada, Masaki Fujita, Toshiro Hara

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A boy developed ipsilateral axillary lymphadenitis after Bacillus Calmette-Guérin (BCG) inoculation at the age of 5 months. Subsequently, he was diagnosed with X-linked chronic granulomatous disease (CGD) by the nitroblue tetrazolium assay when he was 4 years old. Body computerized tomography (CT) performed at the age of 25 years showed enlarged lymph nodes in the left periclavicular and axillary regions, and was confirmed by gallium scintigraphy. Mycobacterial culture, smear, and polymerase chain reaction (PCR) of the sputum and gastric fluid were negative. Whole-blood IFN-γ assay was negative as well. Mycobacterium bovis BCG was isolated from the lymph node biopsy by PCR amplification and culture. No mutation of the IFN-γ receptor 1 could be identified. In conclusion, CGD can be the underlying condition for BCG-itis; whole-blood IFN-γ assay might be useful in differentiating BCG infection and tuberculosis in CGD patients; BCG vaccination is contraindicated in X-linked CGD.

Original languageEnglish
Pages (from-to)745-747
Number of pages3
JournalEuropean Journal of Pediatrics
Volume168
Issue number6
DOIs
Publication statusPublished - Jun 1 2009

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Chronic Granulomatous Disease
Lymphadenitis
Bacillus
Vaccination
Lymph Nodes
Nitroblue Tetrazolium
Polymerase Chain Reaction
Gallium
Mycobacterium bovis
Sputum
Radionuclide Imaging
Stomach
Tuberculosis
Tomography
Biopsy
Mutation
Infection

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Disseminated bacillus calmette-guérin lymphadenitis in a patient with gp91phox - Chronic granulomatous disease 25 years after vaccination. / Kusuhara, Koichi; Ohga, Shouichi; Hoshina, Takayuki; Saito, Mitsumasa; Sasaki, Yuka; Ishimura, Masataka; Takada, Hidetoshi; Fujita, Masaki; Hara, Toshiro.

In: European Journal of Pediatrics, Vol. 168, No. 6, 01.06.2009, p. 745-747.

Research output: Contribution to journalArticle

Kusuhara, Koichi ; Ohga, Shouichi ; Hoshina, Takayuki ; Saito, Mitsumasa ; Sasaki, Yuka ; Ishimura, Masataka ; Takada, Hidetoshi ; Fujita, Masaki ; Hara, Toshiro. / Disseminated bacillus calmette-guérin lymphadenitis in a patient with gp91phox - Chronic granulomatous disease 25 years after vaccination. In: European Journal of Pediatrics. 2009 ; Vol. 168, No. 6. pp. 745-747.
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